Pharmacogenetics of warfarin - is testing clinically indicated?

Martin, JH (2009) Pharmacogenetics of warfarin - is testing clinically indicated?. Australian Prescriber, 32 3: 76-80.

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Author Martin, JH
Title Pharmacogenetics of warfarin - is testing clinically indicated?
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
Publication date 2009-06-01
Year available 2009
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 32
Issue 3
Start page 76
End page 80
Total pages 5
Editor Dr. John S. Dowden
Place of publication Australia
Publisher National Prescribing Service
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
920299 Health and Support Services not elsewhere classified
1115 Pharmacology and Pharmaceutical Sciences
Abstract Pharmacogenetics is genetic testing to optimise prescribing for individual patients. Warfarin is a potential candidate for pharmacogenetic testing as it is commonly used, has a narrow therapeutic window and its mechanism of action and elimination pathways involve receptors and enzymes that are polymorphic. Polymorphism is found in vitamin K epoxide reductase and cytochrome P450 2C9. Pharmacogenetic testing is not yet routine because alone it does not predict all the variability in a patient's response to warfarin so its contribution to improved clinical outcomes is uncertain.
Keyword anticoagulation
cytochrome
vitamin K
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Thu, 03 Sep 2009, 17:57:59 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute