Reduced susceptibility to cefepime among escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase

Doi, Yohei, Paterson, David L., Adams-Haduch, Jennifer M., Sidjabat, Hanna E., O'Keefe, Alexandra, Endimiani, Andrea and Bonomo, Robert A. (2009) Reduced susceptibility to cefepime among escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. Antimicrobial Agents and Chemotherapy, 53 7: 3159-3161. doi:10.1128/AAC.00133-09

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Author Doi, Yohei
Paterson, David L.
Adams-Haduch, Jennifer M.
Sidjabat, Hanna E.
O'Keefe, Alexandra
Endimiani, Andrea
Bonomo, Robert A.
Title Reduced susceptibility to cefepime among escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase
Formatted title
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
1098-6596
Publication date 2009-07-01
Year available 2009
Sub-type Article (original research)
DOI 10.1128/AAC.00133-09
Open Access Status File (Publisher version)
Volume 53
Issue 7
Start page 3159
End page 3161
Total pages 3
Editor George M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society of Microbiology
Language eng
Subject C1
920109 Infectious Diseases
110309 Infectious Diseases
Abstract Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two-to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.
Formatted abstract
Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.
Keyword H-10 helix
Escherichia coli (E. coli)
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID T32 AI007333
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
ERA 2012 Admin Only
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 17:56:34 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research