MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

Bastiani, M, Liu, L, Hill, M. M., Jedrychowski, M. P., Nixon, S. J., Lo, H. P., Abankwa, D, Luetterforst, R, Fernandez-Rojo, M, Breen, M. R., Gygi, S. P., Vinten, J, Walser, P. J., North, K. N., Hancock, J. F., Pilch, P. F. and Parton, R. G. (2009) MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. The Journal of Cell Biology, 185 7: 1259-1273. doi:10.1083/jcb.200903053

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Author Bastiani, M
Liu, L
Hill, M. M.
Jedrychowski, M. P.
Nixon, S. J.
Lo, H. P.
Abankwa, D
Luetterforst, R
Fernandez-Rojo, M
Breen, M. R.
Gygi, S. P.
Vinten, J
Walser, P. J.
North, K. N.
Hancock, J. F.
Pilch, P. F.
Parton, R. G.
Title MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
Journal name The Journal of Cell Biology   Check publisher's open access policy
ISSN 0021-9525
Publication date 2009-06-01
Year available 2009
Sub-type Article (original research)
DOI 10.1083/jcb.200903053
Open Access Status File (Publisher version)
Volume 185
Issue 7
Start page 1259
End page 1273
Total pages 15
Editor Tom Misteli
Place of publication New York, NY, United States
Publisher Rockefeller University Press
Language eng
Abstract Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.
Keyword Cell Biology
Cell Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DK046200
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 135 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 17:55:56 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience