Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis

Ganesvaran, G., Greer, J. M. and Pender, M. P. (2009) Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis. Multiple Sclerosis, 15 6: 763-766. doi:10.1177/1352458509103612


Author Ganesvaran, G.
Greer, J. M.
Pender, M. P.
Title Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis
Journal name Multiple Sclerosis   Check publisher's open access policy
ISSN 1352-4585
Publication date 2009-06-01
Year available 2009
Sub-type Article (original research)
DOI 10.1177/1352458509103612
Open Access Status
Volume 15
Issue 6
Start page 763
End page 766
Total pages 4
Editor Alan J Thompson
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Subject C1
110703 Autoimmunity
110706 Immunogenetics (incl. Genetic Immunology)
110904 Neurology and Neuromuscular Diseases
920108 Immune System and Allergy
Abstract Introduction We identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis within a total group of 692 patients with MS.
Formatted abstract
INTRODUCTION: We identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis within a total group of 692 patients with MS.

RESULTS: There was a high (80%) incidence of brainstem and/or cerebellar involvement and a high mean (+/-SD) Multiple Sclerosis Severity Score (6.06 +/- 2.88) in this subgroup. Of the patients who were human leukocyte antigen typed, 53% carried the MS-associated allele, DRB1*1501, and 27% carried the psoriasis-associated DRB1*07 allele.

CONCLUSION: The high incidence of brainstem and cerebellar involvement might be explained by the greater severity of MS and the high frequency (60%) of carriage of DRB1*04, DRB1*07, and/or DRB1*13 alleles, which are associated with brainstem and cerebellar involvement in MS.
Keyword brainstem
cerebellum
Hla
multiple sclerosis
psoriasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
 
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Created: Thu, 03 Sep 2009, 17:55:22 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research