Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

Dawson, Paul A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S. M., McGuckin, M. A. and Markovich, D. (2009) Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse. Gut, 58 7: 910-919. doi:10.1136/gut.2007.147595


Author Dawson, Paul A.
Huxley, S.
Gardiner, B.
Tran, T.
McAuley, J. L.
Grimmond, S. M.
McGuckin, M. A.
Markovich, D.
Title Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse
Journal name Gut   Check publisher's open access policy
ISSN 0017-5749
Publication date 2009-07-01
Year available 2009
Sub-type Article (original research)
DOI 10.1136/gut.2007.147595
Open Access Status
Volume 58
Issue 7
Start page 910
End page 919
Total pages 10
Editor Robin C. Spiller
Place of publication England, UK
Publisher B M J Group
Language eng
Subject C1
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
920105 Digestive System Disorders
0606 Physiology
060603 Animal Physiology - Systems
Abstract Objective: Sulfate (SO(4)(2-)) is an abundant component intestinal mucins and its content is decreased in certain gastrointestinal diseases, including inflammatory bowel disease. In this study, the hyposulfataemic NaS1 transporter null (Nas1(-/-)) mice were used to the physiological consequences of disturbed sulfate homeostasis on (1) intestinal sulfomucin content and mRNA expression; (2) intestinal permeability and proliferation; (3) dextran sulfate sodium (DSS)-induced colitis; and (4) intestinal barrier function against the bacterial pathogen, Campylobacter jejuni.
Keyword Gastroenterology & Hepatology
Gastroenterology & Hepatology
GASTROENTEROLOGY & HEPATOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 03 Sep 2009, 17:53:44 EST by Mr Andrew Martlew on behalf of School of Biomedical Sciences