Diversity of Group B Streptococcus serotypes causing urinary tract infection in adults

Ulett, Kimberly B., Benjamin, William H., Zhuo, Fenglin, Xiao, Meng, Kong, Fanrong, Gilbert, Gwendolyn L., Schembri, Mark A. and Ulett, Glen C. (2009) Diversity of Group B Streptococcus serotypes causing urinary tract infection in adults. Journal of Clinical Microbiology, 47 7: 2055-2060. doi:10.1128/JCM.00154-09

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Author Ulett, Kimberly B.
Benjamin, William H.
Zhuo, Fenglin
Xiao, Meng
Kong, Fanrong
Gilbert, Gwendolyn L.
Schembri, Mark A.
Ulett, Glen C.
Title Diversity of Group B Streptococcus serotypes causing urinary tract infection in adults
Journal name Journal of Clinical Microbiology   Check publisher's open access policy
ISSN 0095-1137
1098-660X
Publication date 2009-05-13
Year available 2009
Sub-type Article (original research)
DOI 10.1128/JCM.00154-09
Open Access Status File (Publisher version)
Volume 47
Issue 7
Start page 2055
End page 2060
Total pages 6
Editor Andrew B Orderdonk
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Serotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized. We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. Patients who had GBS cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. Demographic data were obtained by reviewing medical records. Isolates were serotyped by latex agglutination and multiplex PCR-reverse line blotting (mPCR/RLB). Antibiotic susceptibilities were determined by disc diffusion. GBS was cultured from 387/34,367 consecutive urine samples (1.1%): 62 patients had bacteriuria of > 10(7) CFU/liter and at least one UTI symptom; of these patients, 31 had urinary leukocyte esterase and pyuria (others not tested), 50 (81%) had symptoms consistent with cystitis, and 12 (19%) had symptoms of pyelonephritis. Compared with controls (who had GBS isolated without symptoms), a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotyping results were consistent between latex agglutination and mPCR/RLB for 331/387 (85.5%) isolates; 22 (5.7%) and 7 (1.8%) isolates were nontypeable with antisera and by mPCR/RLB, respectively; and 45/56 (80.4%) isolates with discrepant results were typed by mPCR/RLB as belonging to serotype V. Serotypes V, Ia, and III caused the most UTIs; serotypes II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS.
Keyword Nonpregnant adults
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 455901
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 03 Sep 2009, 17:53:26 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences