Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin

Hsu, J. Y. -C., Chen, A. C. H., Keleher, A., McMillan, N. A. J. and Antonsson, A. (2009) Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin. Journal of Medical Virology, 81 8: 1444-1449. doi:10.1002/jmv.21529

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Author Hsu, J. Y. -C.
Chen, A. C. H.
Keleher, A.
McMillan, N. A. J.
Antonsson, A.
Title Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin
Journal name Journal of Medical Virology   Check publisher's open access policy
ISSN 1096-9071
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/jmv.21529
Open Access Status
Volume 81
Issue 8
Start page 1444
End page 1449
Total pages 6
Editor Zuckerman, A. J.
Place of publication New York, U.S.
Publisher Wiley-Liss
Language eng
Subject C1
111202 Cancer Diagnosis
110309 Infectious Diseases
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920102 Cancer and Related Disorders
920109 Infectious Diseases
920117 Skin and Related Disorders
Abstract Cutaneous human papillomavirus (HPV) types are commonly found in normal skin, and some of them have been suspected to play a role in the development of non-melanoma skin cancer. This present study is divided into three sections, the aims of this study were to examine if certain HPV-types persist over time and if HPV-types are shared within families. From the first part of the study, swab samples from foreheads were collected for three longitudinal studies from one family with a newborn baby. Five specific HPV-types were isolated from the family with a newborn, with HPV-5 and FA67 being found at various time points and prevalence rates in all four members of the family. Part 2 consisted of a followed up study from two families with a 6 years interval. Six of the family members were found to have at least one of the HPV-types identified in the family 6 years earlier. Many of the HPV-types identified were shared within the families studied. Part 3 of this study involved weekly samples from four healthy females for 4 months. Among the four healthy individuals, 11%, 65%, and 56% of the weekly samples were HPV-DNA positive with one individual HPV-negative. All specimens were tested for HPV-DNA by PCR using the broad range HPV-type primer pair FAP59/64. The positive samples were HPV-type determined by cloning and sequencing. Specific cutaneous HPV-types persist over long periods of time in healthy skin in most individuals investigated and certain HPVs are shared between family members.
Keyword HPV
Asymptomatic infection
Persistent Infection
Healthy skin
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Thu, 03 Sep 2009, 17:53:14 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute