Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis

Walterfang, Mark, Wood, Amanda G., Reutens, David C., Wood, Stephen J., Chen, Jian, Velakoulis, Dennis, McGorry, Patrick .D. and Pantelis, Christos (2009) Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis. Psychiatry Research: Neuroimaging, 173 1: 77-82. doi:10.1016/j.pscychresns.2008.09.007

Author Walterfang, Mark
Wood, Amanda G.
Reutens, David C.
Wood, Stephen J.
Chen, Jian
Velakoulis, Dennis
McGorry, Patrick .D.
Pantelis, Christos
Title Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
Journal name Psychiatry Research: Neuroimaging   Check publisher's open access policy
ISSN 0925-4927
Publication date 2009-07-15
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.pscychresns.2008.09.007
Open Access Status DOI
Volume 173
Issue 1
Start page 77
End page 82
Total pages 6
Editor Monte S. Buchsbaum
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1109 Neurosciences
Abstract Reductions in the size of the anterior callosum have been described for both first-episode and established schizophrenia and bipolar affective disorder, but never in individuals with psychotic bipolar disorder. We recruited 110 first-episode psychosis subjects (74 schizophrenia spectrum and 36 affective psychosis) and 36 age- and gender-matched controls. The callosum was extracted from a mid-sagittal slice from T1-weighted magnetic resonance images, and total area, length and curvature of the callosum were compared. The schizophrenia-spectrum group showed reductions in thickness of the genu across schizophreniform and schizoaffective disorder and schizophrenia, and the schizoaffective disorder group also showed an increase in thickness in the splenium and isthmus. None of these changes were seen in the affective disorder group, although a non-significant increase in the region of the isthmus and splenium was seen, particularly in the depressed group. Psychotic affective disorders do not show the anterior callosal reductions that are seen in the schizophrenia-spectrum group at first episode. The schizoaffective patients show additional posterior callosal expansions that may be a marker of an affective diathesis. This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis.
Keyword White matter
Anterior Cingulate Cortex
Anterior Callosum
White matterInterhemispheric
Bipolar disorder
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 350241
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 17:52:27 EST by Mr Andrew Martlew on behalf of Centre For Magnetic Resonance