Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007

Hawser, Stephen P., Bouchillon, Samuel K., Hoban, Daryl J., Badal, Robert E., Hsueh, Po-Ren and Paterson, David L. (2009) Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007. Antimicrobial Agents and Chemotherapy, 53 8: 3280-3284. doi:10.1128/AAC.00426-09

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Author Hawser, Stephen P.
Bouchillon, Samuel K.
Hoban, Daryl J.
Badal, Robert E.
Hsueh, Po-Ren
Paterson, David L.
Title Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007
Formatted title
Emergence of high levels of extended-spectrum-β-lactamase-producing gram-negative bacilli in the Asia-Pacific region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
1098-6596
Publication date 2009-08-01
Sub-type Article (original research)
DOI 10.1128/AAC.00426-09
Open Access Status File (Publisher version)
Volume 53
Issue 8
Start page 3280
End page 3284
Total pages 5
Editor George M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject C1
110309 Infectious Diseases
920109 Infectious Diseases
Formatted abstract
Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum β-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella oxytoca were 79.0%, 69.4%, and 100%, respectively. ESBL-positive E. coli rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species, including ESBL-positive isolates with the exception of Pseudomonas aeruginosa isolates (<90% susceptible to all study drugs) and ESBL-positive Klebsiella pneumoniae isolates (<90% susceptible to all study drugs except imipenem). Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. A decline in ampicillin-sulbactam activity was noted, with only 34.5% of all Enterobacteriaceae inhibited in this study.
Keyword Klebsiella pneumoniae
Escherichia Coli
Enterobacteriaceae
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
ERA 2012 Admin Only
 
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Created: Thu, 03 Sep 2009, 17:48:39 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research