Semantic activation in Parkinson's disease patients on and off levodopa

Angwin, Anthony J., Arnott, Wendy L., Copland, David A., Haire, Miriam P. L., Murdoch, Bruce E., Silburn, Peter A. and Chenery, Helen J. (2009) Semantic activation in Parkinson's disease patients on and off levodopa. Cortex, 45 8: 950-959. doi:10.1016/j.cortex.2009.02.012


Author Angwin, Anthony J.
Arnott, Wendy L.
Copland, David A.
Haire, Miriam P. L.
Murdoch, Bruce E.
Silburn, Peter A.
Chenery, Helen J.
Title Semantic activation in Parkinson's disease patients on and off levodopa
Formatted title
Semantic activation in Parkinson’s disease patients on and off levodopa
Journal name Cortex   Check publisher's open access policy
ISSN 0010-9452
1973-8102
Publication date 2009-09-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.cortex.2009.02.012
Open Access Status
Volume 45
Issue 8
Start page 950
End page 959
Total pages 10
Place of publication Milano, Italy
Publisher Elsevier Masson
Language eng
Subject C1
920201 Allied Health Therapies (excl. Mental Health Services)
170204 Linguistic Processes (incl. Speech Production and Comprehension)
Abstract Research suggests that dopamine may exert a neuromodulatory influence on automatic spreading activation within semantic networks. In order to investigate the influence of dopamine depletion on semantic activation in Parkinson's disease (PD), nine patients with PD performed a lexical decision task when on and off levodopa medication. Eleven healthy controls matched to the PD patients in terms of sex, age and education also participated in the study. Both directly related word pairs (e.g., tiger - stripe) and indirectly related word pairs (word pairs related via a mediating word, e.g., chalk - black) were used to measure semantic activation across stimulus onset asynchronies (SOAs) of 270 msec, 520 msec and 1020 msec. Analysis of variance statistics revealed that the activation of directly related and indirectly related targets was slower for the PD group relative to the control group. Within group comparisons revealed further changes to semantic activation in PD patients off medication, with no activation of directly or indirectly related target words evident in PD patients off medication. These results further clarify the nature of dopamine's neuromodulatory influence on semantic activation, and suggest that the nature of altered semantic activation in PD may depend on the magnitude of dopamine depletion. (C) 2009 Elsevier Srl. All rights reserved.
Formatted abstract
Research suggests that dopamine may exert a neuromodulatory influence on automatic spreading activation within semantic networks. In order to investigate the influence of dopamine depletion on semantic activation in Parkinson’s disease (PD), nine patients with PD performed a lexical decision task when on and off levodopa medication. Eleven healthy controls matched to the PD patients in terms of sex, age and education also participated in the study. Both directly related word pairs (e.g., tiger – stripe) and indirectly related word pairs (word pairs related via a mediating word, e.g., chalk – black) were used to measure semantic activation across stimulus onset asynchronies (SOAs) of 270 msec, 520 msec and 1020 msec. Analysis of variance statistics revealed that the activation of directly related and indirectly related targets was slower for the PD group relative to the control group. Within group comparisons revealed further changes to semantic activation in PD patients off medication, with no activation of directly or indirectly related target words evident in PD patients off medication. These results further clarify the nature of dopamine’s neuromodulatory influence on semantic activation, and suggest that the nature of altered semantic activation in PD may depend on the magnitude of dopamine depletion.
© 2009 Elsevier Srl. All rights reserved.
Keyword Dopamine
Automatic spreading activation
Language
Parkinson's disease
Semantic priming
Spreading activation
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID A00105401
Institutional Status UQ
Additional Notes Special Issue on "Parkinson's Disease, Language and Cognition". Author prepress title: "Spreading activation in Parkinson’s disease patients on and off levodopa".

 
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Created: Thu, 03 Sep 2009, 17:48:14 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences