Impaired semantic inhibition during lexical ambiguity repetition in parkinson's disease

Copland, David A., Sefe, Gameli, Ashley, Jane, Hudson, Carrie and Chenery, Helen J. (2009) Impaired semantic inhibition during lexical ambiguity repetition in parkinson's disease. Cortex, 45 8: 943-949. doi:10.1016/j.cortex.2009.02.023

Author Copland, David A.
Sefe, Gameli
Ashley, Jane
Hudson, Carrie
Chenery, Helen J.
Title Impaired semantic inhibition during lexical ambiguity repetition in parkinson's disease
Journal name Cortex   Check publisher's open access policy
ISSN 0010-9452
Publication date 2009-09-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.cortex.2009.02.023
Open Access Status DOI
Volume 45
Issue 8
Start page 943
End page 949
Total pages 7
Editor Sergio Della Sala
Place of publication Milan, Italy
Publisher Elsevier Masson
Language eng
Subject 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
170204 Linguistic Processes (incl. Speech Production and Comprehension)
Abstract Impairments of semantic processing and inhibition have been observed in Parkinson's disease (PD), however, the consequences of faulty meaning selection and suppression have not been considered in terms of subsequent lexical processing. The present study employed a lexical ambiguity repetition paradigm where the first presentation of an ambiguity paired with a target biasing its dominant or subordinate meaning (e.g., bank - money or bank - river) was followed after several intervening trials by a presentation of the same ambiguity paired with a different target that biases the same (congruent) or a different (incongruent) meaning to that biased on the first presentation. Meaning dominance (dominant or subordinate weaker meanings) and interstimulus interval (ISI) were manipulated. Analyses conducted on the second presentation indicated priming of congruent meanings and no priming for the incongruent meanings at both short and long ISIs in the healthy controls, consistent with suppression of meanings competing with the representation biased in the first presentation. In contrast, the PD group failed to dampen activation for the incongruent meaning at the long ISI when the first presentation was subordinate. This pattern is consistent with an impairment of meaning suppression which is observed under controlled processing conditions and varies as a function of meaning dominance of the first presentation. These findings further refine our understanding of lexical-semantic impairments in PD and suggest a mechanism that may contribute to discourse comprehension impairments in this population
Keyword Parkinson's disease
Lexical Decision
semantic priming
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 03 Sep 2009, 17:48:12 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research