Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered

McPherson, S., Jonsson, J. R., Cowin, GJ, O'Rourke, P., Clouston, A. D., Volp, A., Horsfall, L., Jothimani, D., Fawcett, J., Galloway, G. J., Benson, M. and Powell, E. E. (2009) Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. Journal of Hepatology, 51 2: 389-397. doi:10.1016/j.jhep.2009.04.012


Author McPherson, S.
Jonsson, J. R.
Cowin, GJ
O'Rourke, P.
Clouston, A. D.
Volp, A.
Horsfall, L.
Jothimani, D.
Fawcett, J.
Galloway, G. J.
Benson, M.
Powell, E. E.
Title Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered
Journal name Journal of Hepatology   Check publisher's open access policy
ISSN 0168-8278
1600-0641
0169-5185
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jhep.2009.04.012
Open Access Status
Volume 51
Issue 2
Start page 389
End page 397
Total pages 9
Editor Robert M. Colomb
C. P. Day
Place of publication Netherlands Elsevier
Publisher Elseiver BV
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110307 Gastroenterology and Hepatology
Abstract Background/Aims: Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, the accuracy of MRS/MRI for grading the severity of steatosis has not been addressed. The aims of this study were (1) to determine whether MRS and MRI can discriminate grades of steatosis in a large cohort of consecutive patients with a wide spectrum of liver disease aetiology and severity (2) to evaluate the effect of hepatic fibrosis, inflammation and iron on quantitation of intrahepatocellular lipid (IHCL) by these techniques.
Keyword Magnetic resonance imaging
Fatty Liver Disease
Fibrosis
Steatosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Thu, 03 Sep 2009, 17:45:34 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital