CtBPs promote cell survival through the maintenance of mitotic fidelity

Bergman, Lee M., Birts, Charles N., Darley, Matthew, Gabrielli, Brian and Blaydes, Jeremy P. (2009) CtBPs promote cell survival through the maintenance of mitotic fidelity. Molecular and Cellular Biology, 29 16: 4539-4551. doi:10.1128/MCB.00439-09

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Author Bergman, Lee M.
Birts, Charles N.
Darley, Matthew
Gabrielli, Brian
Blaydes, Jeremy P.
Title CtBPs promote cell survival through the maintenance of mitotic fidelity
Journal name Molecular and Cellular Biology   Check publisher's open access policy
ISSN 0270-7306
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1128/MCB.00439-09
Open Access Status File (Publisher version)
Volume 29
Issue 16
Start page 4539
End page 4551
Total pages 13
Editor Roger J. Davis
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract CtBPs (CtBP1 and CtBP2) act in the nucleus as transcriptional corepressors and in the cytoplasm as regulators of Golgi apparatus fission. Studies in which the expression or function of CtBPs has been inhibited have independently identified roles for CtBPs in both suppressing apoptosis and promoting cell cycle progression. Here, we have analyzed the consequences of ablating CtBP expression in breast cancer-derived cell lines. We found that loss of CtBP expression suppresses cell proliferation through a combination of apoptosis, reduction in cell cycle progression, and aberrations in transit through mitosis. The third phenotype includes errors in mitotic chromosome segregation that are associated with decreased association of the chromosome passenger protein aurora B with mitotic chromatin and that are likely to be a primary cause of the proapoptotic and antiproliferative effects of CtBP loss. We also show that loss of CtBP expression results in the activation of the transcription factor p53 and that loss of p53 function renders cells more susceptible to CtBP small interfering RNA-induced apoptosis.
Keyword Mitotic
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2003:713
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 17:45:11 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute