Dietary protein during gestation affects placental development in heifers

Sullivan, T. M., Micke, G. C., Magalhaes, R. S., Phillips, N. J. and Perry, V. E. A. (2009) Dietary protein during gestation affects placental development in heifers. Theriogenology, 72 4: 427-438. doi:10.1016/j.theriogenology.2009.03.018

Author Sullivan, T. M.
Micke, G. C.
Magalhaes, R. S.
Phillips, N. J.
Perry, V. E. A.
Title Dietary protein during gestation affects placental development in heifers
Journal name Theriogenology   Check publisher's open access policy
ISSN 0093-691X
Publication date 2009-09-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.theriogenology.2009.03.018
Open Access Status Not yet assessed
Volume 72
Issue 4
Start page 427
End page 438
Total pages 12
Place of publication Philadelphia, PA, U.S.A.
Publisher Elsevier
Language eng
Subject C1
8303 Livestock Raising
070201 Animal Breeding
Abstract The influence of nutritional protein during the first and second trimesters of pregnancy on placental measures at term and caruncle numbers in the uteri of adult offspring was determined in composite beef heifers. At artificial insemination (AI), heifers were divided by weight and composite genotype into four dietary treatment groups, identified by the level of protein components fed during the first and second trimesters: high/high (HH), high/low (HL), low/high (LH), low/low (LL). Expelled placentas were collected and weighed, and cotyledons were dissected, counted, weighed, and measured. Uteri from mature female offspring were dissected at slaughter and caruncles counted. The number of cotyledons in the expelled placenta was increased by high dietary protein in the second trimester (P = 0.02) and varied with genotype (P = 0.03). Placental weight was influenced by maternal undernutrition during early gestation dependent on dam genotype (P = 0.001). Placental efficiency, as determined by calf weight:placental weight, increased with dam age (P = 0.03). Calf birth weight was closely associated with placental weight (P = 0.002) and cotyledonary weight (P = 0.001) and surface area (P = 0.04), but not with the number of cotyledons. Leptin concentrations during early (R = -0.29) and late gestation (R = -0.25) correlated with placental weight, and Insulin-like growth factor binding proteins throughout gestation correlated with the number of cotyledons (R = -0.28 to-0.33). The number of uterine caruncles in the nonpregnant adult offspring did not correlate with the dam's genotype, nutrition treatment, or cotyledon number in the expelled placenta. © 2009 Elsevier Inc. All rights reserved.
Keyword Cattle
Dietary protein
Fetal development
Maternal nutrient restriction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Public Health Publications
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 17:43:15 EST by Mr Andrew Martlew on behalf of Faculty Of Nat Resources, Agric & Veterinary Sc