Cortical NMDA receptor expression in human chronic alcoholism: Influence of the TaqIA allele of ANKK1

Ridge, Justin P. and Dodd, Peter R. (2009) Cortical NMDA receptor expression in human chronic alcoholism: Influence of the TaqIA allele of ANKK1. Neurochemical Research, 34 10: 1775-1782. doi:10.1007/s11064-009-9941-8


Author Ridge, Justin P.
Dodd, Peter R.
Title Cortical NMDA receptor expression in human chronic alcoholism: Influence of the TaqIA allele of ANKK1
Formatted title
Cortical NMDA receptor expression in human chronic alcoholism: Influence of the TaqIA allele of ANKK1
Journal name Neurochemical Research   Check publisher's open access policy
ISSN 0364-3190
1573-6903
Publication date 2009-03-13
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s11064-009-9941-8
Open Access Status Not yet assessed
Volume 34
Issue 10
Start page 1775
End page 1782
Total pages 8
Editor Abel Lajtha
Kazuhiro Ikenaka
Henry Sershen
Place of publication Springer
Publisher Netherlands
Language eng
Subject C1
060410 Neurogenetics
060105 Cell Neurochemistry
060110 Receptors and Membrane Biology
110902 Cellular Nervous System
920414 Substance Abuse
Abstract Real-time RT-PCR normalized to GAPDH was used to assay N-methyl-d-aspartate (NMDA) receptor NR1, NR2A and NR2B subunit mRNA in human autopsy cortex tissue from chronic alcoholics with and without comorbid cirrhosis of the liver and matched controls. Subunit expression was influenced by the subject's genotype. The TaqIA polymorphism selectively modulated NMDA receptor mean transcript expression in cirrhotic-alcoholic superior frontal cortex, in diametrically opposite ways in male and female subjects. Genetic make-up may differentially influence vulnerability to brain damage by altering the excitation: inhibition balance, particularly in alcoholics with comorbid cirrhosis of the liver. The TaqIA polymorphism occurs within the poorly characterised ankyrin-repeat containing kinase 1 (ANKK1) gene. Using PCR, ANKK1 mRNA transcript was detected in inferior temporal, occipital, superior frontal and primary motor cortex of control human brain. ANKK1 expression may mediate the influence of the TaqIA polymorphism on phenotype.
Keyword Excitotoxicity
Pathogenesis
Genetic susceptibility
Alcohol dependence
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 401551
AA12404
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 03 Sep 2009, 17:41:36 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences