CT-X antigen expression in human breast cancer

Grigoriadis, Anita, Caballero, Otavia L., Hoek, Keith S., da Silva, Leonard, Chen, Yao-Tseng, Shin, Sandra J., Jungbluth, Achim A., Miller, Lance D., Clouston, David, Cebon, Jonathan, Old, Lloyd J., Lakhani, Sunil R., Simpson, Andrew J.G. and Neville, A. Munro Neville (2009) CT-X antigen expression in human breast cancer. Proceedings of the National Academy of Sciences, 106 32: 13493-13498. doi:10.1073/pnas.0906840106

Author Grigoriadis, Anita
Caballero, Otavia L.
Hoek, Keith S.
da Silva, Leonard
Chen, Yao-Tseng
Shin, Sandra J.
Jungbluth, Achim A.
Miller, Lance D.
Clouston, David
Cebon, Jonathan
Old, Lloyd J.
Lakhani, Sunil R.
Simpson, Andrew J.G.
Neville, A. Munro Neville
Title CT-X antigen expression in human breast cancer
Journal name Proceedings of the National Academy of Sciences   Check publisher's open access policy
ISSN 0027-8424
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1073/pnas.0906840106
Open Access Status Not Open Access
Volume 106
Issue 32
Start page 13493
End page 13498
Total pages 6
Editor Randy Schekman
Place of publication Washington, DC, United States
Publisher National Acadamy of Sciences
Language eng
Subject 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
111203 Cancer Genetics
920102 Cancer and Related Disorders
9205 Specific Population Health (excl. Indigenous Health)
920507 Women's Health
Abstract Cancer/testis (CT) genes are predominantly expressed in human germ line cells, but not somatic tissues, and frequently become activated in different cancer types. Several CT antigens have already proved to be useful biomarkers and are promising targets for therapeutic cancer vaccines. The aim of the present study was to investigate the expression of CT antigens in breast cancer. Using previously generated massively parallel signature sequencing (MPSS) data, together with 9 publicly available gene expression datasets, the expression pattern of CT antigens located on the X chromosome (CT-X) was interrogated. Whereas a minority of unselected breast cancers was found to contain CT-X transcripts, a significantly higher expression frequency was detected in estrogen and progesterone receptor (ER) negative breast cancer cell lines and primary breast carcinomas. A coordinated pattern of CT-X antigen expression was observed, with MAGEA and NY-ESO-1/CTAG1B being the most prevalent antigens. Immunohistochemical staining confirmed the correlation of CT-X antigen expression and ER negativity in breast tumors and demonstrated a trend for their coexpression with basal cell markers. Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful.
Keyword Cancer/testis antigens
Estrogen Receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 17:41:13 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research