Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection

Laurence, J., Wang, C., Park, E., Buchanan, A., Clouston, A. D., Alen, R., Mccaughan, G., Bishop, G. and Sharland, A. (2008) Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation, 85 9: 1357-1361. doi:10.1097/TP.0b013e31816fc27f


Author Laurence, J.
Wang, C.
Park, E.
Buchanan, A.
Clouston, A. D.
Alen, R.
Mccaughan, G.
Bishop, G.
Sharland, A.
Title Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
1534-6080
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1097/TP.0b013e31816fc27f
Open Access Status Not yet assessed
Volume 85
Issue 9
Start page 1357
End page 1361
Total pages 5
Editor D. Sachs
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 920118 Surgical Methods and Procedures
110323 Surgery
Abstract In a well-characterized rat model of liver transplantation, Piebald Virol Glaxo strain livers are accepted long term in fully mismatched Dark Agouti recipients (tolerance; TOL), but rejected in Lewis recipients (rejection; REJ). Spontaneous tolerance induction is associated with increased interferon-[gamma] expression, and we examined the role of the interferon-[gamma]-inducible immunomodulatory enzyme indoleamine dioxygenase (IDO) in this model. On day 3 after transplantation, IDO expression in the spleen of TOL recipients was significantly greater than in REJ. The B-cell population accounted for this early IDO increase. Intragraft expression of IDO increased to the same extent in both TOL and REJ. IDO inhibition for 7 days after transplantation reduced survival, but did not cause acute rejection of the liver in the TOL model. In conclusion, the differential IDO expression by B lymphocytes in the spleen of TOL recipients is not critical for preventing acute rejection.
Keyword Transplantation tolerance
Indoleamine dioxygenase
1-Methyl tryptophan
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 21 Aug 2009, 21:21:21 EST by Denise Wilson on behalf of Medicine - Princess Alexandra Hospital