Pertussis in infants: How to protect the vulnerable?

Chuk, L-m R, Stephen Lambert, May, M.L., Beard, F. H., Sloots, T. P., Selvey, C. E. and Nissen, Michael D. (2008) Pertussis in infants: How to protect the vulnerable?. Communicable Diseases Intelligence, 32 4: 449-456.

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Author Chuk, L-m R
Stephen Lambert
May, M.L.
Beard, F. H.
Sloots, T. P.
Selvey, C. E.
Nissen, Michael D.
Title Pertussis in infants: How to protect the vulnerable?
Journal name Communicable Diseases Intelligence   Check publisher's open access policy
ISSN 1447-4514
Publication date 2008-12-01
Year available 2008
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 32
Issue 4
Start page 449
End page 456
Total pages 8
Editor Mackay, I.
Place of publication Woden, A.C.T., Australia
Publisher Australian Government Department of Health and Ageing, Office of Health Protection, Survelliance Branch
Language eng
Subject C1
270000 Biological Sciences
270303 Virology
270304 Infectious Agents
C Society
920109 Infectious Diseases
06 Biological Sciences
1117 Public Health and Health Services
1103 Clinical Sciences
Abstract In terms of adverse outcomes, infants remain the group most vulnerable to severe pertussis disease. Adult household contact is thought to be the main source of transmission to infants. This study reviews exposure history, vaccination status, admission outcome and quality of discharge coding of hospitalised infants with pertussis at a tertiary paediatric hospital. We identified cases between 1997 and 2006 from 2 sources: hospital discharge coding and positive Bordetella pertussis results from the hospital laboratory database. We assessed the completeness of each of these sources, compared with the dataset of all identified cases. We identified 55 hospitalised infants with pertussis. The 35 cases (64%) less than 3 months of age had greater risk of Intensive Care Unit admission, higher mortality, and were more likely to have parents as an identified source. On admission, only 5 cases (9%) were more than 2 weeks overdue for their previous scheduled pertussis vaccination. Discharge coding was more sensitive for identifying cases than the laboratory database. Nine cases (16%) had incorrect discharge coding. Even infants up to date for pertussis vaccine can have severe disease requiring hospitalisation. Immunising parents planning to have, or who have had, a newborn baby may help to prevent pertussis in infants. Commun Dis Intell 2008;32:449-456.
Keyword Whooping cough,
Bordetella pertussis
Household transmission
Pertussis vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Clinical Medical Virology Centre Publications
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Created: Sat, 15 Aug 2009, 00:52:17 EST by Lesley Arnicar on behalf of Faculty of Science