Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion (Systematic Review)

Webster, Joan, Bel-Syer, Sally E. M. and Foxlee, Ruth (2009) Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion (Systematic Review). Cochrane Database of Systematic Reviews, 3: 1-27. doi:10.1002/14651858.CD007948

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Author Webster, Joan
Bel-Syer, Sally E. M.
Foxlee, Ruth
Title Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion (Systematic Review)
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2009-07-01
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/14651858.CD007948
Open Access Status File (Publisher version)
Issue 3
Start page 1
End page 27
Total pages 27
Place of publication Oxford, United Kingdom
Publisher John Wiley and Sons
Language eng
Subject 321102 Clinical Nursing - Primary (Preventative)
111002 Clinical Nursing: Primary (Preventative)
C1
Formatted abstract
Background
Blood for transfusion may become contaminated at any point between collection and transfusion and may result in bacteraemia (the presence of bacteria in the blood), severe illness or even death for the blood recipient. Donor arm skin is one potential source of blood contamination, so it is usual to cleanse the skin with an antiseptic before blood donation. One-step and two-step alcohol based antiseptic regimens are both commonly advocated but there is uncertainty as to which is most effective.

Objectives
To assess the effects of cleansing the skin of blood donors with alcohol in a one-step compared with alcohol in a two-step procedure to prevent contamination of collected blood or bacteraemia in the recipient.

Search strategy
We searched the Cochrane Wounds Group Specialised Register (March 10 2009); The Cochrane Central Register of Controlled Trials (CENTRAL) The Cochrane Library 2009, Issue 1; Ovid MEDLINE - (1950 to February Week 4 2009); Ovid EMBASE - (1980 to 2009 Week 9); and EBSCO CINAHL - (1982 to February Week 4 2009). We also searched the reference lists of key papers.

Selection criteria
All randomised trials (RCTs) comparing alcohol based donor skin cleansing in a one-step versus a two-step process that includes alcohol and any other antiseptic for pre-venepuncture skin cleansing were considered. Quasi randomised trials were to have been considered in the absence of RCTs.

Data collection and analysis
Two review authors independently assessed studies for inclusion.

Main results
No studies (RCTs or quasi RCTs) met the inclusion criteria.

Authors' conclusions
We did not identify any eligible studies for inclusion in this review. It is therefore unclear whether a two-step, alcohol followed by antiseptic skin cleansing process prior to blood donation confers any reduction in the risk of blood contamination or bacteraemia in blood recipients, or conversely whether a one-step process increases risk above that associated with a two-step process.

Keyword Skin preparation
antiseptic
bacteraemia
contamination of blood
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2010 Higher Education Research Data Collection
School of Nursing, Midwifery and Social Work Publications
 
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Created: Fri, 31 Jul 2009, 19:40:47 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work