Effects of restricted basilar papillar lesions and hair cell regeneration on auditory forebrain frequency organization in adult European Starlings

Irvine, Dexter R. F., Brown, Mel, Kamke, Marc R. and Rubel, Edwin W. (2009) Effects of restricted basilar papillar lesions and hair cell regeneration on auditory forebrain frequency organization in adult European Starlings. The Journal of Neuroscience, 29 21: 6871-6882. doi:10.1523/JNEUROSCI.5513-08.2009

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Author Irvine, Dexter R. F.
Brown, Mel
Kamke, Marc R.
Rubel, Edwin W.
Title Effects of restricted basilar papillar lesions and hair cell regeneration on auditory forebrain frequency organization in adult European Starlings
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2009-05-27
Year available 2009
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.5513-08.2009
Open Access Status File (Publisher version)
Volume 29
Issue 21
Start page 6871
End page 6882
Total pages 12
Editor John H. R. Maunsell
Place of publication United States
Publisher Society for Neuroscience
Language eng
Subject C1
110903 Central Nervous System
110906 Sensory Systems
920107 Hearing, Vision, Speech and Their Disorders
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract The frequency organization of neurons in the forebrain Field L complex (FLC) of adult starlings was investigated to determine the effects of hair cell (HC) destruction in the basal portion of the basilar papilla (BP) and of subsequent HC regeneration. Conventional microelectrode mapping techniques were used in normal starlings and in lesioned starlings either 2 d or 6-10 weeks after aminoglycoside treatment. Histological examination of the BP and recordings of auditory brainstem evoked responses confirmed massive loss of HCs in the basal portion of the BP and hearing losses at frequencies >2 kHz in starlings tested 2 d after aminoglycoside treatment. In these birds, all neurons in the region of the FLC in which characteristic frequencies (CFs) normally increase from 2 to 6 kHz had CF in the range of 2-4 kHz. The significantly elevated thresholds of responses in this region of altered tonotopic organization indicated that they were the residue of prelesion responses and did not reflect CNS plasticity. In the long-term recovery birds, there was histological evidence of substantial HC regeneration. The tonotopic organization of the high-frequency region of the FLC did not differ from that in normal starlings, but the mean threshold at CF in this frequency range was intermediate between the values in the normal and lesioned short-recovery groups. The recovery of normal tonotopicity indicates considerable stability of the topography of neuronal connections in the avian auditory system, but the residual loss of sensitivity suggests deficiencies in high-frequency HC function.
Keyword Partial Cochlear Lesions
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DC02854
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Fri, 31 Jul 2009, 01:16:42 EST by Debra McMurtrie on behalf of Queensland Brain Institute