Hemodialysis versus continuous veno-venous hemodiafiltration in the management of severe valproate overdose

Kay T. D., Playford, H. R. and Johnson D. W. (2003) Hemodialysis versus continuous veno-venous hemodiafiltration in the management of severe valproate overdose. Clinical Nephrology, 59 1: 56-58.


Author Kay T. D.
Playford, H. R.
Johnson D. W.
Title Hemodialysis versus continuous veno-venous hemodiafiltration in the management of severe valproate overdose
Formatted title
Haemodialysis versus continuous veno-venous haemodiafiltration in the management of severe valproate overdose
Journal name Clinical Nephrology   Check publisher's open access policy
ISSN 0301-0430
Publication date 2003-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 59
Issue 1
Start page 56
End page 58
Total pages 3
Place of publication Munich
Publisher Dustri
Language eng
Subject 110312 Nephrology and Urology
Formatted abstract
Valproate intoxication is a relatively common clinical problem that can result in coma, respiratory depression, pancytopenia, hemodynamic instability and death [Fernandez et al. 1996, Franssen et al. 1999]. The drug's relatively low molecular weight, small volume of distribution and saturable protein-binding render it potentially amenable to extracorporeal removal (hemofiltration, hemodialysis or hemoperfusion), but published experience is scarce.

This report describes a woman with a potentially fatal sodium valproate overdose, who did not respond to continuous veno-venous hemodiafiltration, but was successfully treated with low-flux hemodialysis. Based on our experience, we recommend hemodialysis for serious valproate intoxication.
Keyword bipolar affective disorder
dialysis
valproic acid
ACID OVERDOSE
HEMOPERFUSION
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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