The biology of caveolae: Achievements and perspectives

Parat, Marie-Odile (2009). The biology of caveolae: Achievements and perspectives. In Kwang W. Jeon (Ed.), International review of cell and molecular biology (pp. 117-162) Maryland Heights, MO, United States: Academic Press. doi:10.1016/S1937-6448(08)01804-2

Author Parat, Marie-Odile
Title of chapter The biology of caveolae: Achievements and perspectives
Title of book International review of cell and molecular biology
Place of Publication Maryland Heights, MO, United States
Publisher Academic Press
Publication Year 2009
Sub-type Research book chapter (original research)
DOI 10.1016/S1937-6448(08)01804-2
Open Access Status DOI
Year available 2011
Series International Review of Cell and Molecular Biology
ISBN 9780123748041
ISSN 1937-6448
Editor Kwang W. Jeon
Volume number 273
Chapter number 4
Start page 117
End page 162
Total pages 46
Total chapters 8
Language eng
Abstract/Summary Caveolae are specialized plasma membrane subdomains visualized more than 50 years ago as cave-like invaginations at the cell surface. They are rich in cholesterol, glycosphingolipids, and lipid-anchored proteins. Their signaling and trafficking capabilities influence multiple cellular processes, and are believed to require caveolin-1, a major protein component of caveolae in most cell types. Today the structure and functions of caveolae are still the objects of intense research. Caveolin-1 is not anymore the only protein known to be required for caveolae formation, and functions for caveolin-1 outside of caveolae are being unveiled. Studying the phenotype of mice lacking caveolae has largely confirmed the roles attributed to this organelle and its defining protein. The consequences of mutation of ablation of caveolins in human disease are emerging. Recent evidence further suggests that caveolae and caveolin can be targeted for therapeutic purposes.
Keyword Caveolin
Molecular dissection
Post translational modification
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Mon, 20 Jul 2009, 20:31:52 EST by Charna Kovacevic on behalf of School of Pharmacy