Interventions for psychosexual dysfunction in women treated for gynaecological malignancy

Flynn, Paul, Kew, Fiona and Kisely, Steve R. (2009) Interventions for psychosexual dysfunction in women treated for gynaecological malignancy. Cochrane Database of Systematic Reviews, 2: 1-23. doi:10.1002/14651858.CD004708.pub2

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Author Flynn, Paul
Kew, Fiona
Kisely, Steve R.
Title Interventions for psychosexual dysfunction in women treated for gynaecological malignancy
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2009-04-15
Year available 2009
Sub-type Article (original research)
DOI 10.1002/14651858.CD004708.pub2
Open Access Status File (Publisher version)
Issue 2
Start page 1
End page 23
Total pages 24
Editor Chris Williams
Place of publication Oxford, United Kingdom
Publisher John Wiley and Sons
Language eng
Subject 11 Medical and Health Sciences
Abstract Background
Formatted abstract
Psychosexual dysfunction (sexual difficulties not directly due to physical factors) is known to be a common complication of treatment for gynaecological cancer. It has a considerable impact on quality of life (QoL) for the increasing number of women who are survivors of gynaecological cancer.

To determine the effectiveness of interventions for psychosexual dysfunction in women who have been treated for gynaecological malignancy (cancer of uterine cervix, uterine corpus, ovary, vulva).

Search methods

We searched the Cochrane Central Register of Controlled Trials (CENTRAL, up to October 2008), MEDLINE (1950 to October 2008), EMBASE (1982 to October 2008), CINAHL (1980 to October 2008) and PsycINFO (1806 to October 2008). We hand searched reference lists from eligible trials.

Selection criteria

We selected all randomized controlled trials (RCTs) of a medical or psychological intervention to prevent or treat psychosexual dysfunction in adult women previously treated for gynaecological cancer.

Data collection and analysis

We selected five studies for inclusion in this review and analysed any outcome data relating to resumption of sexual intercourse, DSMIV diagnoses or validated scales of sexual functioning. Sensitivity analysis was performed where possible.

Main results

The review included data from 5 studies, comprising a total of 413 patients, examining 5 different interventions. One trial suggested a short-term benefit for the use of vaginal Dienoestrol in women after pelvic radiotherapy (NNT = 4). Another trial suggested a shortterm benefit for one regime of low dose-rate brachytherapy over another but this  modality is not in widespread use. Studies of a Clinical Nurse Specialist intervention, Psychoeducational Group Therapy and a Couple-Coping intervention, did not show any significant benefit. All the studies were of poor methodological quality.  

Authors’ conclusions
There is no convincing evidence to support the use of any interventions for psychosexual dysfunction in women treated for gynaecological cancer. There is a need for more studies of high methodological quality. 
Keyword Psychosexual dysfunction
Women - Health
Gynaecological malignancy
Cancer of uterus
Uterine cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Centre for Health Data Services
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Fri, 17 Jul 2009, 01:35:56 EST by Marisol da Silva on behalf of Faculty Of Health Sciences