Recommendations for the use of icodextrin in peritoneal dialysis patients

Johnson, David W., Agar, John, Collins, John, Disney, Alex, Harris, David C. H., Ibels, Lloyd, Irish, Ashley, Saltissi, David and Suranyi, Michael (2003) Recommendations for the use of icodextrin in peritoneal dialysis patients. Nephrology, 8 1: 1-7. doi:10.1046/j.1440-1797.2003.00117.x


Author Johnson, David W.
Agar, John
Collins, John
Disney, Alex
Harris, David C. H.
Ibels, Lloyd
Irish, Ashley
Saltissi, David
Suranyi, Michael
Title Recommendations for the use of icodextrin in peritoneal dialysis patients
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
1440-1797
Publication date 2003-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1046/j.1440-1797.2003.00117.x
Open Access Status
Volume 8
Issue 1
Start page 1
End page 7
Total pages 7
Place of publication Carlton, Vic.
Publisher Blackwell Science
Language eng
Subject 110312 Nephrology and Urology
Formatted abstract
SUMMARY:Icodextrin is a starch-derived, high molecular weight glucose polymer, which has been shown to promote sustained ultrafiltration equivalent to that achieved with hypertonic (3.86%/4.25%) glucose exchanges during prolonged intraperitoneal dwells (up to 16 h).

Patients with impaired ultrafiltration, particularly in the settings of acute peritonitis, high transporter status and diabetes mellitus, appear to derive the greatest benefit from icodextrin with respect to augmentation of dialytic fluid removal, amelioration of symptomatic fluid retention and possible prolongation of technique survival. Glycaemic control is also improved by substituting icodextrin for hypertonic glucose exchanges in diabetic patients.

Preliminary in vitro and ex vivo studies suggest that icodextrin demonstrates greater peritoneal membrane biocompatibility than glucose-based dialysates, but these findings need to be confirmed by long-term clinical studies.

This paper reviews the available clinical evidence pertaining to the safety and efficacy of icodextrin and makes recommendations for its use in peritonal dialysis.
Keyword blood glucose analysis
CAPD
dialysis solutions
drug eruptions
glucans
isotonic solutions
kidney failure
practice guidelines
ultrafiltration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Review article

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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