Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum

Piper, Michael, Plachez, Celine, Zalucki, Oressia, Fothergill, Thomas, Goudreau, Guy, Erzurumlu, Reha, Gu, Chenghua and Richards, Linda J. (2009) Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum. Cerebral Cortex, 19 Supplement 1: i11-i21. doi:10.1093/cercor/bhp027


Author Piper, Michael
Plachez, Celine
Zalucki, Oressia
Fothergill, Thomas
Goudreau, Guy
Erzurumlu, Reha
Gu, Chenghua
Richards, Linda J.
Title Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1460-2199
1047-3211
Publication date 2009-07-01
Year available 2009
Sub-type Article (original research)
DOI 10.1093/cercor/bhp027
Open Access Status DOI
Volume 19
Issue Supplement 1
Start page i11
End page i21
Total pages 10
Editor Rakic Pasko
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 110903 Central Nervous System
110902 Cellular Nervous System
920111 Nervous System and Disorders
C1
Abstract Pioneer axons from the cingulate cortex initiate corpus callosum (CC) development, yet nothing is known about the molecules that regulate their guidance. We demonstrate that neuropilin 1 (Npn1) plays an integral role in the development of the CC. Npn1 is localized to axons of cingulate neurons as they cross the midline, and multiple class 3 semaphorins (Semas) are expressed around the developing CC, implicating these guidance molecules in the regulation of Npn1-expressing axons emanating from the cingulate cortex. Furthermore, axons from the cingulate cortex display guidance errors in Npn1(Sema-) mice, a knockin mouse line in which Npn1 is unable to bind Semas. Analysis of mice deficient in the transcription factor Emx2 demonstrated that the cingulate cortex of these mice was significantly reduced in comparison to wild-type controls at E17 and that the CC was absent in rostral sections. Expression of Npn1 was absent in rostral sections of Emx2 mutants, suggesting that Npn1-expressing cingulate pioneers are required for CC formation. These data highlight a central role for Npn1 in the development of projections from the cingulate cortex and further illustrate the importance of these pioneer axons in the formation of the CC.
Keyword Axon guidance
Cingulate Cortex
Emx2
Neuropilin
Sema
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 401616
NS039050
Institutional Status UQ
Additional Notes Cortical Development: Neural Stem Cells to Neural Circuits Chania, Greece, May 22-25, 2008

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 60 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Jul 2009, 23:17:19 EST by Debra McMurtrie on behalf of Queensland Brain Institute