Response: Iron Therapy in Renal Transplant Recipients

Johnson, David W., Mudge, David W., Atcheson, Bronwyn, Taylor, Paul J., Sturtevant, Joanna M., Hawley, Carmel M., Campbell, Scott B., Isbel, Nicole M., Nicol, David L. and Pillans, Peter (2004) Response: Iron Therapy in Renal Transplant Recipients. Transplantation, 78 8: 1240-1240. doi:10.1097/01.TP.0000137102.92992.5F

Author Johnson, David W.
Mudge, David W.
Atcheson, Bronwyn
Taylor, Paul J.
Sturtevant, Joanna M.
Hawley, Carmel M.
Campbell, Scott B.
Isbel, Nicole M.
Nicol, David L.
Pillans, Peter
Title Response: Iron Therapy in Renal Transplant Recipients
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
Publication date 2004-10-27
Year available 2004
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1097/01.TP.0000137102.92992.5F
Open Access Status Not yet assessed
Volume 78
Issue 8
Start page 1240
End page 1240
Total pages 1
Place of publication Baltimore
Publisher Lippincott Williams & Wilkins
Language eng
Subject 110312 Nephrology and Urology
Formatted abstract
As Drs. Lorenz and Sunder-Plassmann point out in their opening paragraph (1), our recently published randomized controlled trial (2) demonstrated the important new finding that oral iron can be administered concomitantly with mycophenolate mofetil in new kidney transplant recipients without any appreciable effect on mycophenolic acid exposure, as measured by area-under-the-curve (AUC).

Although they additionally expressed concern regarding the potential for iron to exert harmful effects on the kidney, we are not aware of any clinical evidence that oral iron supplementation is nephrotoxic in the posttransplant setting. In our study, the incidence of delayed graft function, defined as the need for dialysis posttransplantation, was comparably low in both patients who did, and those who did not, receive iron supplements (12.5% versus 8.3%, respectively, p=0.74).

Moreover, Lorenz and Sunder-Plassmann’s (1) comment that rejection rates were lower in the group who did not receive iron is misleading, given that we reported that the observed differences were not statistically significant on either univariate analysis (p=0.35) or multivariate analysis (p=0.99).
Keyword Anemia
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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