Polyfluoroalkyl chemicals in pooled blood serum from infants, children and adults in Australia

Toms, Leisa-Maree L., Calafat, Antonia M., Kato, Kyoto, Thompson, Jack, Harden, Fiona, Hobson, Peter, Sjodin, Andreas and Mueller, Jochen F. (2009) Polyfluoroalkyl chemicals in pooled blood serum from infants, children and adults in Australia. Environmental Science and Technology, 43 11: 4194-4199. doi:10.1021/es900272u

Author Toms, Leisa-Maree L.
Calafat, Antonia M.
Kato, Kyoto
Thompson, Jack
Harden, Fiona
Hobson, Peter
Sjodin, Andreas
Mueller, Jochen F.
Title Polyfluoroalkyl chemicals in pooled blood serum from infants, children and adults in Australia
Journal name Environmental Science and Technology   Check publisher's open access policy
ISSN 0013-936X
Publication date 2009-04-27
Year available 2009
Sub-type Article (original research)
DOI 10.1021/es900272u
Open Access Status DOI
Volume 43
Issue 11
Start page 4194
End page 4199
Total pages 5
Editor Jerald Schnoor
Place of publication Washington, D.C.
Publisher American Chemical Society
Language eng
Subject 050206 Environmental Monitoring
111799 Public Health and Health Services not elsewhere classified
920405 Environmental Health
969999 Environment not elsewhere classified
Abstract Polyfluoroalkyl chemicals (PFCs) have been used worldwide for more than 50 years in a wide variety of industrial and consumer products. Limited data exist on human exposure to PFCs in the Southern Hemisphere. Human blood serum collected in southeast Queensland, Australia, in 2006−2007 from 2420 donors was pooled according to age (cord blood, 0−0.5, 0.6−1, 1.1−1.5, 1.6−2, 2.1−2.5, 2.6−3, 3.1−3.5, 3.6−4, 4.1−6, 6.1−9, 9.1−12, 12.1−15, 16−30, 31−45, 46−60, and >60 years) and gender and was analyzed for eight PFCs. Across all pools, perfluorooctane sulfonate (PFOS) was detected at the highest mean concentration (15.2 ng/mL) followed by perfluorooctanoate (PFOA, 6.4 ng/mL), perfluorohexane sulfonate (PFHxS, 3.1 ng/mL), perfluorononanoate (PFNA, 0.8 ng/mL), 2-(N-methyl-perfluorooctance sulfonamide) acetate (Me-PFOSA-AcOH, 0.66 ng/mL), and perfluorodecanoate (PFDeA, 0.29 ng/mL). Perfluorooctane sulfonamide was detected in only 24% of the pools, and 2-(N-ethylperfluorooctane sulfonamide) acetate was detected in only one. PFOS concentrations were significantly higher in pools from adult males than from adult females (p = 0.002); no gender differences were apparent in the pools from children (<12 years old). The highest mean concentrations of PFOA, PFHxS, PFNA, PFDeA, and Me-PFOSA-AcOH were found in children <15 years, while PFOS was highest in adults >60 years. Investigation into the sources and exposure pathways in Australia, in particular for children, is necessary as well as continued biomonitoring to determine the potential effects on human concentrations as a result of changes in the PFC manufacturing practices, including the cessation of production of several PFCs. Copyright © 2009 American Chemical Society
Keyword Perfluorooctane sulfonate pfos
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
National Research Centre for Environmental Toxicology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 107 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 114 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 18 Jun 2009, 00:01:34 EST by Mrs Leisa-maree Toms on behalf of National Res Centre For Environmental Toxicology