Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release

Lin, Chun Xiang (Cynthia), Qiao, Shi Zhang, Yu, Cheng Zhong, Ismadji, Suryadi and Lu, Gao Qing (Max) (2009) Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release. Microporous and Mesoporous Materials, 117 1-2: 213-219. doi:10.1016/j.micromeso.2008.06.023

Author Lin, Chun Xiang (Cynthia)
Qiao, Shi Zhang
Yu, Cheng Zhong
Ismadji, Suryadi
Lu, Gao Qing (Max)
Title Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release
Journal name Microporous and Mesoporous Materials   Check publisher's open access policy
ISSN 1387-1811
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.micromeso.2008.06.023
Open Access Status DOI
Volume 117
Issue 1-2
Start page 213
End page 219
Total pages 7
Place of publication Netherlands
Publisher Elsevier BV
Language eng
Subject C1
100708 Nanomaterials
970103 Expanding Knowledge in the Chemical Sciences
Abstract In this paper, we report the effects of morphology, wall composition of mesoporous materials and different buffer solutions on drug delivery profiles. Hollow spheres of periodic mesoporous organosilica (PMO) were prepared and used as drug carriers which exhibited higher loading capacity and slower release rate compared to the conventional periodic mesoporous silica (PMS) spheres and solid spheres of PMO. This hollow PMO showed promising properties as a reservoir to encapsulate and store larger quantities of guest molecules within its “empty” core. Moreover, its organic reactive sites allowed stronger interactions to the hydrophobic guest molecules, in contrast to inorganic wall possessed by PMS materials. Antibiotic tetracycline was used as a model drug to study the effect of framework difference between PMO and PMS materials on the loading and release processes. Two kinds of release medium, simulated body fluid (SBF) solution (pH 7.4) and phosphate buffer (PB) solution (pH 1.5) were used in this study, which revealed very different release profiles. A slower delivery rate was observed in SBF solution, attributed to the different ionic interactions between the guest molecule and the host material in the two different pH solutions. Overall, hollow PMO shows the lowest release rate and the highest loading amount compared to the other two materials studied herein. The kinetic study reveals that drug release from host material follows the second order kinetic model better than the first order mass transfer model.
Keyword PMO hollow spheres
Mesoporous silica spheres
Drug release
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 28 June 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 100 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 110 times in Scopus Article | Citations
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Created: Sat, 13 Jun 2009, 04:47:11 EST by Siona Saplos on behalf of Office of Sponsored Research