Multiple genetic tests for susceptibility to smoking do not outperform simple family history

Gartner, Coral E., Barendregt, Jan and Hall, Wayne D. (2009) Multiple genetic tests for susceptibility to smoking do not outperform simple family history. Addiction, 104 1: 118-126. doi:10.1111/j.1360-0443.2008.02392.x


Author Gartner, Coral E.
Barendregt, Jan
Hall, Wayne D.
Title Multiple genetic tests for susceptibility to smoking do not outperform simple family history
Journal name Addiction   Check publisher's open access policy
ISSN 1360-0443
0965-2140
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1360-0443.2008.02392.x
Open Access Status
Volume 104
Issue 1
Start page 118
End page 126
Total pages 9
Place of publication Abingdon, U.K.
Publisher Blackwell
Language eng
Subject C1
11 Medical and Health Sciences
1117 Public Health and Health Services
1112 Oncology and Carcinogenesis
1701 Psychology
Abstract To evaluate the utility of using predictive genetic screening of the population for susceptibility to smoking.
Formatted abstract
Aims
To evaluate the utility of using predictive genetic screening of the population for susceptibility to smoking.

Methods

The results of meta-analyses of genetic association studies of smoking behaviour were used to create simulated data sets using Monte Carlo methods. The ability of the genetic tests to screen for smoking was assessed using receiver operator characteristic curve analysis. The result was compared to prediction using simple family history information. To identify the circumstances in which predictive genetic testing would potentially justify screening we simulated tests using larger numbers of alleles (10, 15 and 20) that varied in prevalence from 10 to 50% and in strength of association [relative risks (RRs) of 1.2–2.1].

Results

A test based on the RRs and prevalence of five susceptibility alleles derived from meta-analyses of genetic association studies of smoking performed similarly to chance and no better than the prediction based on simple family history. Increasing the number of alleles from five to 20 improved the predictive ability of genetic screening only modestly when using genes with the effect sizes reported to date.

Conclusions

This panel of genetic tests would be unsuitable for population screening. This situation is unlikely to be improved upon by screening based on more genetic tests. Given the similarity with associations found for other polygenic conditions, our results also suggest that using multiple genes to screen the general population for genetic susceptibility to polygenic disorders will be of limited utility.
Keyword Genetic susceptibility
Genetic test
Nicotine dependence
Smoking
Screening
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID AA07535
Institutional Status UQ
Additional Notes Published Online: 12 Dec 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Public Health Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 13 Jun 2009, 04:00:12 EST by Siona Saplos on behalf of Faculty Of Health Sciences