Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis

Da Silva, Leonard, Buck, Lyndall, Simpson, Peter T., Reid, Lynne, McCallum, Naomi, Madigan, Barry J. and Lakhani, Sunil R. (2009) Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Archiv, 454 1: 107-114. doi:10.1007/s00428-008-0700-z


Author Da Silva, Leonard
Buck, Lyndall
Simpson, Peter T.
Reid, Lynne
McCallum, Naomi
Madigan, Barry J.
Lakhani, Sunil R.
Title Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis
Journal name Virchows Archiv   Check publisher's open access policy
ISSN 1035-3712
1448-5494
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s00428-008-0700-z
Open Access Status
Volume 454
Issue 1
Start page 107
End page 114
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer Berlin
Language eng
Subject C1
11 Medical and Health Sciences
110316 Pathology (excl. Oral Pathology)
Abstract Adenoid cystic carcinoma (ACC) of the breast is a rare tumour. Its recognition as a special type of breast carcinoma is very important because its prognosis is better than the not-otherwise-specified invasive ductal carcinoma and its treatment may not include axillary dissection. Tubular adenosis (TA) is a very rare condition of the breast that is histologically benign; however, it has been described in association with invasive ductal carcinoma. There are scant data regarding the molecular genomic alterations in ACC of the breast and no data has been presented on TA. Herein, we provide a morphological characterisation of TA arising synchronically with ACC in the breast. To characterise these lesions, we performed ultrastructural analysis, three-dimensional reconstruction and molecular analysis using immunohistochemistry and comparative genomic hybridisation. The copy number alterations found in ACC were restricted to small deletions on 16p and 17q only, whereas the TA harboured gains on 1q, 5p, 8q, 10q, 11p and 11q and losses on 1p, 10q, 11q, 12q, 14q, 15q and 16q. These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC.
Keyword Adenoid cystic carcinoma
Tubular adenosis
Microglandular adenosis
Breast cancer
Comparative genomic hybridisation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 25 November 2008 ,In print Volume 454, Number 1 / January, 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
School of Medicine Publications
 
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Created: Fri, 12 Jun 2009, 23:01:39 EST by Siona Saplos on behalf of Faculty Of Health Sciences