Informative study designs to identify true parameter-covariate relationships

Han, P. Y., Kirkpatrick, C. M. J. and Green, B. (2009) Informative study designs to identify true parameter-covariate relationships. Journal of Pharmacokinetics and Pharmacodynamics, 36 2: 147-163. doi:10.1007/s10928-009-9115-y


Author Han, P. Y.
Kirkpatrick, C. M. J.
Green, B.
Title Informative study designs to identify true parameter-covariate relationships
Journal name Journal of Pharmacokinetics and Pharmacodynamics   Check publisher's open access policy
ISSN 1567-567X
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1007/s10928-009-9115-y
Open Access Status DOI
Volume 36
Issue 2
Start page 147
End page 163
Total pages 17
Editor Aarons, L.
Rowland, M.
Ludden, T.
Jusko, W. J.
Place of publication United States
Publisher Springer New York LLC
Language eng
Subject C1
060102 Bioinformatics
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract This study explored how study design influences the probability of selecting a ‘true’ covariate from two competing covariate models. The probability of selecting the ‘True Model’ (lean body weight on clearance) over the ‘False Model’ (total body weight (WT) on clearance) was compared for designs where WT was either lognormally distributed (i.e. non-stratified), or stratified into 3 equal strata. The probability of selecting the ‘True Model’ increased as the WT inclusion criterion widened, and was always greater under the stratified design. Incorporating stratification into study designs, in combination with a wide covariate range, can aid identification of true parameter–covariate relationships. This has particular importance if the model is to be extrapolated beyond the studied population (e.g. dosing in obesity).
Keyword Population modelling
Nonmem
Study Design
Covariate selection
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Wed, 10 Jun 2009, 22:22:57 EST by Charna Kovacevic on behalf of School of Pharmacy