Novel Synthetic Bio-Mimic Polymers for Cell Delivery

Xiao, Y., Peng, H., Whittaker, A. K. and Crawford, R. (2008). Novel Synthetic Bio-Mimic Polymers for Cell Delivery. In: Bell, J, Yan, C, Ye, L and Zhang, L, Advanced Materials Research: Frontiers in materials science and technology. International Conference on Frontiers in Materials Science & Technology, Brisbane, Australia, (215-222). 26-28 March, 2008. doi:10.4028/0-87849-475-8.215


Author Xiao, Y.
Peng, H.
Whittaker, A. K.
Crawford, R.
Title of paper Novel Synthetic Bio-Mimic Polymers for Cell Delivery
Conference name International Conference on Frontiers in Materials Science & Technology
Conference location Brisbane, Australia
Conference dates 26-28 March, 2008
Proceedings title Advanced Materials Research: Frontiers in materials science and technology   Check publisher's open access policy
Journal name Frontiers in Materials Science and Technology   Check publisher's open access policy
Place of Publication Stafa-Zurich, Switzerland
Publisher Trans Tech Publications
Publication Year 2008
Year available 2008
Sub-type Fully published paper
DOI 10.4028/0-87849-475-8.215
Open Access Status
ISBN 9780878494750
ISSN 1022-6680
Editor Bell, J
Yan, C
Ye, L
Zhang, L
Volume 32
Start page 215
End page 222
Total pages 8
Language eng
Abstract/Summary Cell-based therapy is one of the major potential therapeutic strategies for cardiovascular, neuronal and degenerative diseases in recent years. The aims of this study is to develop a novel bio-mimic polymeric materials which will facilitate the delivery cells, control cell bioactivities and enhance the focal integration of graft cells with host tissues. We synthesized a novel tri-block copolymer, methoxy-terminated poly (ethylene glycol) (MPEG)-polyL-lactide (PLLA)-polylysine (PLL) via sequential polymerization of PLLA onto MPEG, followed by ring opening polymerization of PLL onto the functionalized chain end. The triblock copolymer (5%) was then mixed with high molecular weight PLLA (95%) to form cell-delivery membranes. The spectra of copolymers were determined by NMR and ATR-FTIR spectroscopy. Human ostceblasts were used for testing biocompatibility and initial cellular reaction. It was noted that no cytotoxicity was detectable in our synthesized copolymers. Compared with pure PLLA and diblock copolymers, the triblock copolymers showed significantly better cell adhesion and proliferation. Interestingly we identified that cellular activity (attachment, proliferation and differentiation) could be regulated by the molecular weight and composition of the triblock copolymers. In conclusion controllable synthetic copolymers can be designed and synthesized to modulate cellular function in facilitating tissue repair and regeneration.
Subjects 0303 Macromolecular and Materials Chemistry
0304 Medicinal and Biomolecular Chemistry
Keyword Promoting Chondrocyte Attachment
Rgd Peptide Modification
Poly(Lactic Acid-Co-Lysine)
Copolymer
Growth
Poly(L-Lactide)
Polyesters
Chemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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