Synthesis of (S,R,R,R)-α,α′-Iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol)

Wang, Nai-Xing, Yu, An-Guang, Wang, Gui-Xia, Zhang, Xiu-Hui, Lu, Qian-Shu and Li, Zhen (2007) Synthesis of (S,R,R,R)-α,α′-Iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol). Synthesis, 2007 8: 1154-1158. doi:10.1055/s-2007-965993

Author Wang, Nai-Xing
Yu, An-Guang
Wang, Gui-Xia
Zhang, Xiu-Hui
Lu, Qian-Shu
Li, Zhen
Title Synthesis of (S,R,R,R)-α,α′-Iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol)
Journal name Synthesis   Check publisher's open access policy
ISSN 0039-7881
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1055/s-2007-965993
Open Access Status
Volume 2007
Issue 8
Start page 1154
End page 1158
Total pages 5
Place of publication Stuttgart
Publisher Georg Thieme
Language eng
Subject 0305 Organic Chemistry
Abstract The β1-adrenergic antagonist (S,R,R,R)-α,α′-iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol) was synthesized from natural chiral pool starting materials through an efficient, convergent synthetic strategy. The cyclization mechanism of the key step was investigated using computer modeling and is discussed.
Keyword (S,R,R,R)
chiral pool
synthesis design
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Advanced Imaging Publications
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Created: Mon, 01 Jun 2009, 19:10:09 EST by Sophie Jordan on behalf of Centre for Advanced Imaging