Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin

Chiang, Alan K. S., Srivastava, Gopesh, Lau, Patrick W. F. and Ho, Faith C. S. (1996) Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin. Human Pathology, 27 7: 701-707. doi:10.1016/S0046-8177(96)90401-3


Author Chiang, Alan K. S.
Srivastava, Gopesh
Lau, Patrick W. F.
Ho, Faith C. S.
Title Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin
Journal name Human Pathology   Check publisher's open access policy
ISSN 0046-8177
1532-8392
Publication date 1996-07-01
Sub-type Article (original research)
DOI 10.1016/S0046-8177(96)90401-3
Volume 27
Issue 7
Start page 701
End page 707
Total pages 7
Editor R. V. Lloyd
Place of publication Kidlington, Oxford, UK
Publisher Saunders
Language eng
Subject 110316 Pathology (excl. Oral Pathology)
Formatted abstract
Although nasal lymphomas showing midfacial destructive lesions had been classified as T-cell lymphomas, their exact cellular origin is still unclear. Although they usually express a restricted number of T-cell-related antigens, namely, CD2, CD43, and CD45R0, other pan-T or subset-T-lineage antigens, such as CD3 (membrane), CD5, CD4, CD8, and CD7, are frequently absent. Conversely, they often express a natural killer (NK) cell-associated antigen, CD56, but lack other mature NK markers.

To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data.

Two cases of nasal lymphomas with CD2+CD3(Leu4)−CD19−CD56+ phenotype were shown to express truncated 1.0-kb Tβ and multiple unrearranged Tδ transcripts with germline TCR β, γ, δ, and immunoglobulin heavy-chain joining region (JH) genes, consistent with NK cell lineage. In contrast, one case of nasal lymphoma with CD2+CD3(Leu4)+CD8+CD19−CD56+ phenotype expressed full-length Tα, Tβ, and Tγ transcripts with rearranged TCR β, γ, and deleted TCR δ genes, indicating T-cell lineage.

These results support the view that nasal lymphomas can be separated into NK-cell and T-cell neoplasms, based on differences in genotypic characteristics. The possibility of these tumors being derived from a putative common precursor cell merits further investigation.
Keyword T-cell receptor
gene transcription
gene rearrangement
nasal lymphomas
natural killer cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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