Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

Yang, Zeng-Jie, Ellis, Tammy L., Markant, Shirley L., Read, Tracy-Ann, Kessler, Jessica D, Melissa Bourboulas, Schuller, Ulrich, Machold, Robert, Fishell, Gord, Rowitch, David H., Wainwright, Brandon J. and Wechsler-Reya, Robert J. (2008) Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell, 14 2: 135-145. doi:10.1016/j.ccr.2008.07.003


Author Yang, Zeng-Jie
Ellis, Tammy L.
Markant, Shirley L.
Read, Tracy-Ann
Kessler, Jessica D
Melissa Bourboulas
Schuller, Ulrich
Machold, Robert
Fishell, Gord
Rowitch, David H.
Wainwright, Brandon J.
Wechsler-Reya, Robert J.
Title Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Formatted title
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Journal name Cancer Cell   Check publisher's open access policy
ISSN 1535-6108
1878-3686
Publication date 2008-08-12
Sub-type Article (original research)
DOI 10.1016/j.ccr.2008.07.003
Volume 14
Issue 2
Start page 135
End page 145
Total pages 11
Editor Li-Kuo Su
Place of publication Cambridge, MA, U.S.A.
Publisher Cell Press
Collection year 2009
Language eng
Subject C1
920102 Cancer and Related Disorders
060103 Cell Development, Proliferation and Death
1112 Oncology and Carcinogenesis
Formatted abstract
Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of Shh signaling in neuronal progenitors causes medulloblastoma by 3 months of age. Shh pathway activation in stem cells promotes stem cell proliferation but only causes tumors after commitment to—and expansion of—the neuronal lineage. Notably, tumors initiated in stem cells develop more rapidly than those initiated in progenitors, with all animals succumbing by 3–4 weeks. These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment.
©2008 Elsevier Inc.
Keyword Medulloblastoma
Cellbio
Humdisease
Stemcell
Progenitors
Q-Index Code C1
Q-Index Status Provisional Code

 
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Created: Thu, 14 May 2009, 01:38:45 EST by Jennifer Greder on behalf of Institute for Molecular Bioscience