A patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: a longitudinal psychometric evaluation

Cheng, Karis K. F., Leung, S. F., Liang,Raymond H. S., Tai, Josepha W. M., Yeung,Rebecca M. W. and Thompson, David R. (2009) A patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: a longitudinal psychometric evaluation. Supportive Care In Cancer, 17 4: 389-398. doi:10.1007/s00520-008-0485-2


Author Cheng, Karis K. F.
Leung, S. F.
Liang,Raymond H. S.
Tai, Josepha W. M.
Yeung,Rebecca M. W.
Thompson, David R.
Title A patient-reported outcome instrument to assess the impact of oropharyngeal mucositis on health-related quality of life: a longitudinal psychometric evaluation
Journal name Supportive Care In Cancer   Check publisher's open access policy
ISSN 0941-4355
1433-7339
Publication date 2009-04-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00520-008-0485-2
Open Access Status Not yet assessed
Volume 17
Issue 4
Start page 389
End page 398
Total pages 10
Editor H. J. Senn
Fred Ashbury
Place of publication Berlin, Germany
Publisher Springer International
Language eng
Subject C1
920102 Cancer and Related Disorders
111299 Oncology and Carcinogenesis not elsewhere classified
Formatted abstract
Goals of work.
An oropharyngeal mucositis (OM)-specific health-related quality of life measure (OMQoL) has been developed to assess the impact of OM from the perspective of patients. The current paper describes the convergent, concurrent, and known-group validities and responsiveness in relation to clinical and health outcomes.

Materials and methods.
A multicenter approach was used, and 137 patients treated with different cancer therapies completed the OMQoL and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire [EORTC QLQ-C30 (Ch)] twice over a 4-week period or weekly over a 7-week period, along with concurrent measures of OM and its related symptoms.

Main results.
The OM-related symptom scores correlated highly with the OMQoL, confirming its convergent validity (r = −0.724–−0.971, p < 0.01). Moderate correlations between the subscales of the OMQoL and EORTC QLQ-C30 (Ch) were indicative of good concurrent validity (r = 0.450–0.724, p < 0.01). The OMQoL was able to distinguish between patients with different severities of OM (p < 0.01) and types of cancer therapy (p < 0.01), providing evidence of good known-group validity. The changes in effects sizes corresponding to changes in OM curves indicate that the OMQoL is responsive to changes in OM status.

Conclusions.
These findings suggest that the OMQoL has very good psychometric properties and can be used as a health-related quality of life assessment for cancer patients with OM. Much work is still needed in strengthening the psychometric qualities and interpretability of the OMQoL by demonstrating its ability to detect outcome changes over time.
Keyword oropharyngeal mucositis
Health-related quality of life
measures
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1 KL2 RR02415101
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Nursing, Midwifery and Social Work Publications
 
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Created: Fri, 08 May 2009, 00:27:00 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work