The spectrum of serous cystadenoma of the pancreas: Clinical, pathologic, and surgical aspects.

Pyke, Christopher M., van Heerden, Jon A., Colby, Thomas V., Saar, Michael G. and Weaver, Amy L. (1992) The spectrum of serous cystadenoma of the pancreas: Clinical, pathologic, and surgical aspects.. Annals of Surgery, 215 2: 132-139. doi:10.1097/00000658-199202000-00007


Author Pyke, Christopher M.
van Heerden, Jon A.
Colby, Thomas V.
Saar, Michael G.
Weaver, Amy L.
Title The spectrum of serous cystadenoma of the pancreas: Clinical, pathologic, and surgical aspects.
Journal name Annals of Surgery   Check publisher's open access policy
ISSN 0003-4932
1528-1140
Publication date 1992-02-01
Year available 1992
Sub-type Article (original research)
DOI 10.1097/00000658-199202000-00007
Open Access Status Not yet assessed
Volume 215
Issue 2
Start page 132
End page 139
Total pages 8
Editor Layton F. Rikkers
Place of publication Amsterdam, Netherlands.
Publisher Wolters Kluwer
Language eng
Subject 110323 Surgery
Abstract Serous cystadenoma of the pancreas is a rare lesion thought to be almost invariably benign. Since 1978, 211 cases have been reported in the literature. Some have been recognized by computed tomography (CT) when small and asymptomatic. The authors have reviewed their experience with 40 patients (median follow-up of 1.9 years, maximum of 22.2 years) from 1936 to 1991. One third (13) were asymptomatic, of whom eight (20%) were discovered intraoperatively. Of those 20 who had CT, an unequivocal preoperative diagnosis was reached in none. Needle biopsy proved accurate in two patients. Endoscopic retrograde cholangiopancreatography (ERCP) and biopsy were performed with diagnostic success on one occasion. Three patients presented acutely. The tumor was resected in 90%, with an operative mortality rate of 10%. Enucleation of the tumor without formal anatomic pancreatectomy necessitated reoperation for complications in four of eight patients. Survival after successful resection paralleled expected survival. Serous cystadenoma may be associated with von Hippel-Lindau syndrome. The current role for conservative management remains questionable because of our current inability to reliably differentiate many of these benign neoplasms from malignant cystic neoplasms of the pancreas.
Formatted abstract
Serous cystadenoma of the pancreas is a rare lesion thought to be almost invariably benign. Since 1978, 211 cases have been reported in the literature. Some have been recognized by computed tomography (CT) when small and asymptomatic.

The authors have reviewed their experience with 40 patients (median follow-up of 1.9 years, maximum of 22.2 years) from 1936 to 1991. One third (13) were asymptomatic, of whom eight (20%) were discovered intraoperatively. Of those 20 who had CT, an unequivocal preoperative diagnosis was reached in none. Needle biopsy proved accurate in two patients. Endoscopic retrograde cholangiopancreatography (ERCP) and biopsy were performed with diagnostic success on one occasion. Three patients presented acutely.

The tumor was resected in 90%, with an operative mortality rate of 10%. Enucleation of the tumor without formal anatomic pancreatectomy necessitated reoperation for complications in four of eight patients. Survival after successful resection paralleled expected survival. Serous cystadenoma may be associated with von Hippel-Lindau syndrome.

The current role for conservative management remains questionable because of our current inability to reliably differentiate many of these benign neoplasms from malignant cystic neoplasms of the pancreas.
(C) Lippincott-Raven Publishers.

Keyword Surgery
Surgery
SURGERY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 180 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 219 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 05 May 2009, 21:42:18 EST by Maria Campbell on behalf of Library Corporate Services