Prefrontal and midline interactions mediating behavioural control

Fassbender, Catherine, Hester, Robert, Murphy, Kevin, Foxe, John J., Foxe, Deirdre M. and Garavan, Hugh (2009) Prefrontal and midline interactions mediating behavioural control. European Journal of Neuroscience, 29 1: 181-187. doi:10.1111/j.1460-9568.2008.06557.x

Author Fassbender, Catherine
Hester, Robert
Murphy, Kevin
Foxe, John J.
Foxe, Deirdre M.
Garavan, Hugh
Title Prefrontal and midline interactions mediating behavioural control
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2008.06557.x
Open Access Status Not yet assessed
Volume 29
Issue 1
Start page 181
End page 187
Total pages 7
Editor B. Everitt
Christopher E. Henderson
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Language eng
Subject 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
970117 Expanding Knowledge in Psychology and Cognitive Sciences
Abstract Top-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.
Keyword anterior cingulate cortex
cognitive control
dorsolateral prefrontal cortex
pre-supplementary motor area
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 24 Apr 2009, 22:18:55 EST by Debra McMurtrie on behalf of Queensland Brain Institute