Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals

Grunert, M., Nurcombe, V. and Cool, S. M. (2008) Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals. Current Stem Cell Research and Therapy, 3 1: 1-8. doi:10.2174/157488808783489417


Author Grunert, M.
Nurcombe, V.
Cool, S. M.
Title Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals
Journal name Current Stem Cell Research and Therapy   Check publisher's open access policy
ISSN 1574-888X
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/157488808783489417
Open Access Status
Volume 3
Issue 1
Start page 1
End page 8
Total pages 8
Place of publication Netherlands
Publisher Bentham Science
Language eng
Subject C1
06 Biological Sciences
Abstract The aim of this review is to explore the idea that the glycosaminoglycan sugar heparan sulfate (HS), richly concentrated on the plasma membrane of all animal cells studied so far and a major component of extracellular matrices, is by virtue of its ability to modulate protein gradients and signal transduction, the master regulator of stem cell fate (and thus wound healing). Moreover, the interaction between HS and members of the TGF-β superfamily is emerging as a central tenet for stem cells. The potential significance of this interaction is best understood by examining both how HS modulates ligand interactions and stability, and how it maintains protein gradients with varying degrees of specificity. Importantly, HS also regulates the activity of numerous antagonists, thus underscoring its importance as a primary regulator of stem cell fate decisions.
Keyword BMP
Differentiation
Heparin
Proteoglycan
Stem cell
Wnt
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Mon, 20 Apr 2009, 14:26:58 EST by Timothy Hazelton on behalf of School of Biomedical Sciences