Lung parenchyma at maturity is influenced by postnatal growth but not by moderate pre-term birth in sheep

Maritz, G, Probyn, M, De Matteo, R and Snibson, K (2007) Lung parenchyma at maturity is influenced by postnatal growth but not by moderate pre-term birth in sheep. Neonatology: foetal and neonatal research, 93 1: 28-35. doi:10.1159/000105522


Author Maritz, G
Probyn, M
De Matteo, R
Snibson, K
Title Lung parenchyma at maturity is influenced by postnatal growth but not by moderate pre-term birth in sheep
Journal name Neonatology: foetal and neonatal research   Check publisher's open access policy
ISSN 1661-7800
Publication date 2007-07-12
Year available 2007
DOI 10.1159/000105522
Open Access Status DOI
Volume 93
Issue 1
Start page 28
End page 35
Total pages 8
Editor C. Speer
H. L. Halliday
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Subject C1
110203 Respiratory Diseases
830310 Sheep - Meat
Formatted abstract
Background:
We have recently shown that moderate preterm birth, in the absence of respiratory support, altered the structure of lung parenchyma in young lambs, but the long-term effects are unknown.

Objectives:
To determine whether structural changes persist to maturity, and whether postnatal growth affects lung structure at maturity in sheep. Methods: At approximately 1.2 years after birth, lung parenchyma of sheep born 14 days before term (n = 7) was stereologically compared with that of controls born at term (n = 8, term approx. 146 days).

Results:
Preterm birth per se had no significant effect on lung volume, alveolar number and size, and thicknesses of the alveolar walls and blood-gas barrier. After combining the preterm and term groups, we examined the effects of postnatal growth rates on lung parenchyma. Slower-growing sheep (SG; n = 7: 4 preterm, 3 term) were compared with faster-growing sheep (FG; n = 8: 3 preterm, 5 term). At approximately 1.2 years, the right lung volume, relative to body weight, was significantly lower in SG than FG sheep (p < 0.05) and alveolar number was significantly lower by approximately 44%. The total alveolar internal surface area of the right lung of SG sheep was 38% smaller than in FG sheep; it was also significantly lower when related to both lung and body weight.

Conclusions:
Our data suggest that moderate preterm birth does not cause persistent alterations in lung parenchyma. However, slow postnatal growth in low-birth-weight sheep results in smaller lungs with fewer alveoli and a lower alveolar surface area relative to body weight.

Copyright © 2007 S. Karger AG, Basel

Keyword Preterm birth
Growth rates
Adult sheep
Alveoli
Lung structure
Q-Index Code C1

Document type: Journal Article
Collection: School of Biomedical Sciences Publications
 
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Created: Sat, 18 Apr 2009, 20:34:14 EST by Shirley Rey on behalf of School of Biomedical Sciences