Does moderate preterm birth lead to altered arterial pressure? Studies in sheep

Matteo, Robert De, Stacy, Victoria, Probyn, Megan E., Brew, Nadine, Blasch, Natasha and Harding, Richard (2008) Does moderate preterm birth lead to altered arterial pressure? Studies in sheep. Clinical and Experimental Pharmacology and Physiology, 35 12: 1426-1432. doi:10.1111/j.1440-1681.2008.05014.x

Author Matteo, Robert De
Stacy, Victoria
Probyn, Megan E.
Brew, Nadine
Blasch, Natasha
Harding, Richard
Title Does moderate preterm birth lead to altered arterial pressure? Studies in sheep
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 2008-12-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.2008.05014.x
Volume 35
Issue 12
Start page 1426
End page 1432
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject C1
110203 Respiratory Diseases
970106 Expanding Knowledge in the Biological Sciences
Formatted abstract
1  Low birth weight (LBW) is associated with an increased risk of cardiovascular disease. Preterm birth is a major determinant of LBW and has been shown to result in elevated arterial pressure (AP) in humans, but few studies have investigated the effects of preterm birth in the absence of potentially confounding factors. Our aim was to determine whether moderately preterm birth per se alters the postnatal development of AP in lambs.

2  Preterm lambs were delivered approximately 14 days before term (i.e. ~133 days of gestation); controls were born at term (~147 days). Mean arterial pressure (MAP), heart rate (HR), blood composition and indices of growth were measured at 4 and 8 weeks post term-equivalent age (PTEA). We also studied a separate cohort of preterm and term sheep as young adults (~1.1 years).

3  Preterm lambs had significantly lower birth weights than term lambs, but bodyweights were not significantly different by Day 12 PTEA. In addition, MAP, HR and most blood variables did not differ between term and preterm lambs at 4 or 8 weeks PTEA. Preterm birth per se did not alter MAP or HR in young adult sheep.

4  Low birth weight due to preterm birth does not result in an altered AP during early postnatal life or at maturity. Moderate intrauterine growth restriction (IUGR) due to twinning, which further reduces birth weight, does not affect MAP in preterm lambs. Other factors, such as the degree of prematurity or IUGR, exposure to corticosteroids or postnatal nutrition, may be important in the later development of elevated AP.
Keyword Arterial pressure
Postnatal growth
Preterm Birth
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Biomedical Sciences Publications
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Created: Sat, 18 Apr 2009, 18:34:15 EST by Shirley Rey on behalf of School of Biomedical Sciences