Cadmium-induced synthesis of HSP70 and a role of glutathione in Euglena gracilis

Watanabe, Masumi and Suzuki, Tetsuya (2004) Cadmium-induced synthesis of HSP70 and a role of glutathione in Euglena gracilis. Redox Report, 9 6: 349-353. doi:10.1179/135100004225006867

Author Watanabe, Masumi
Suzuki, Tetsuya
Title Cadmium-induced synthesis of HSP70 and a role of glutathione in Euglena gracilis
Journal name Redox Report   Check publisher's open access policy
ISSN 1351-0002
Publication date 2004-12-01
Sub-type Article (original research)
DOI 10.1179/135100004225006867
Open Access Status
Volume 9
Issue 6
Start page 349
End page 353
Total pages 5
Place of publication Leeds & London, UK; Boston & Philadelphia, USA
Publisher Maney Publishing, on behalf of the Society for Free Radical Research (Australasia)
Language eng
Subject 060199 Biochemistry and Cell Biology not elsewhere classified
Abstract The effect of cadmium-induced oxidative stress, with or without glutathione supplementation, was investigated in the single cell eukaryotic phytoflagellate, Euglena gracilis strains Z and its achlorophyllous mutant SMZ as experimental models. Both these strains actively synthesize thiols to prevent or resist cadmium toxicity. The content of glutathione, as a representative antioxidant, was also examined in both strains. Exposure to cadmium induced heat-shock protein 70 (HSP70) synthesis in both strains of E. gracilis. Glutathione supplementation also induced HSP70. Overall, these results indicate that glutathione was closely linked to the induction of stress-related proteins. The sensitivity to cadmium-stress was higher in strain Z than SMZ. The results suggest that chloroplasts may have a role in the regulation of HSP70 expression. The relationship between HSP70 and GSH levels is still far from understood, and further research may shed light upon their up-regulation in the presence of Cd.
Keyword Euglena Gracilis
Cadmium Stress
Stress-Related Protiens
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
National Research Centre for Environmental Toxicology Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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