Preparation of crosslinked starch microspheres and their drug loading and releasing properties

Fang, Yuan-yuan, Wang, Li-jun, Li, Dong, Li, Bing-zheng, Bhandari, Bhesh, Chen, Xiao Dong and Mao, Zhi-huai (2008) Preparation of crosslinked starch microspheres and their drug loading and releasing properties. Carbohydrate Polymers, 74 3: 379-384. doi:10.1016/j.carbpol.2008.03.005


Author Fang, Yuan-yuan
Wang, Li-jun
Li, Dong
Li, Bing-zheng
Bhandari, Bhesh
Chen, Xiao Dong
Mao, Zhi-huai
Title Preparation of crosslinked starch microspheres and their drug loading and releasing properties
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
Publication date 2008-11-04
Sub-type Article (original research)
DOI 10.1016/j.carbpol.2008.03.005
Open Access Status DOI
Volume 74
Issue 3
Start page 379
End page 384
Total pages 6
Editor J. F.Kennedy
J. R. Mitchell
Place of publication London, England
Publisher Applied Science/Elsevier
Language eng
Subject C1
860199 Processed Food Products and Beverages (excl. Dairy Products) not elsewhere classified
090802 Food Engineering
Abstract Crosslinked anionic starch microspheres were prepared with sodium trimetaphosphate (STMP) as crosslinking agent through 5 h w/o emulsification-crosslinking reaction at 50 °C. Laser diffraction technique and scanning electron microscopy revealed that microspheres had narrow size distribution, good sphericity and fine dispersibility. In addition, drug loading and releasing properties were investigated with Methylene Blue as a model drug on the basis of single-factor study. It was found that the loading ratio of MB was significantly influenced by loading time, dissolution medium, loading temperature as well as MB concentration (P < 0.05). Either the increase of loading time or drug concentration could lead to the increase of drug loading amount of microspheres, however, drug loading amount reached its maximum in NaCl (0.9%) dissolution medium at room temperature. Furthermore, the release profile contained two main expulsion processes: an initial burst release followed by a sustained swelling-controlled release.
Keyword Crosslinked starch microspheres
Drug loading
Drug release
SEM
Particle size
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Agriculture and Food Sciences
 
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Created: Fri, 17 Apr 2009, 23:29:05 EST by Emma Cushworth on behalf of School of Land, Crop and Food Sciences