Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms

Colgrave, Michelle, Kotze, Andrew C., Steven Kopp, McCarthy, James S., Coleman, Glen T. and Craik, David J. (2009) Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms. Acta Tropica, 109 2: 163-166. doi:10.1016/j.actatropica.2008.11.003

Author Colgrave, Michelle
Kotze, Andrew C.
Steven Kopp
McCarthy, James S.
Coleman, Glen T.
Craik, David J.
Title Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms
Journal name Acta Tropica   Check publisher's open access policy
ISSN 0001-706X
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.actatropica.2008.11.003
Open Access Status
Volume 109
Issue 2
Start page 163
End page 166
Total pages 4
Editor Berzins, K.
Guhl, F.
Beier, J.
Place of publication Netherlands
Publisher Elsevier BV
Language eng
Subject C1
030401 Biologically Active Molecules
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Abstract Hookworm infection is a leading cause of maternal and child morbidity in countries of the tropics and subtropics, as well as being an important parasite in companion-animal medicine. The cyclotides are a novel family of cyclic cystine knot containing peptides from plants that have been shown to possess anthelmintic activity against Haemonchus contortus and Trichostrongylus colubriformis, two important gastrointestinal nematodes of sheep. In the current study we demonstrated the in vitro effects of three representative cyclotides, kalata B1, kalata B6 and cycloviolacin O14, on the viability of larval and adult life stages of the dog hookworm Ancylostoma caninum, and larvae of the human hookworm Necator americanus. The cyclotides showed significant anthelmintic activity towards both hookworm species. The different cyclotides showed similar patterns of relative activity as that seen previously with the livestock nematode species. This study demonstrates that cyclotides have promising activity in vitro against important parasites of companion animals and humans.
Keyword Cyclotides
Ancylostoma caninum
Necator americanus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 17 Apr 2009, 00:13:13 EST by Narelle Poole on behalf of School of Veterinary Science