Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects

Chinh, N.T., Quang, N. Q., Thanh, N. X., Dai, B., Geue, J. P., Addison, R. S., Travers, T. and Edstein, M. D. (2009) Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects. Antimicrobial Agents and Chemotherapy, 53 2: 828-831. doi:10.1128/AAC.00927-08

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Author Chinh, N.T.
Quang, N. Q.
Thanh, N. X.
Dai, B.
Geue, J. P.
Addison, R. S.
Travers, T.
Edstein, M. D.
Title Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 1098-6596
0066-4804
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1128/AAC.00927-08
Open Access Status File (Publisher version)
Volume 53
Issue 2
Start page 828
End page 831
Total pages 4
Editor George M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society of Microbiology
Language eng
Subject C1
111502 Clinical Pharmacology and Therapeutics
860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
Abstract The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Fri, 17 Apr 2009, 00:10:59 EST by Barb Clyde on behalf of Centre for Integrated Preclinical Drug Development