Audit of eosinophilic oesophagitis in children post-liver transplantation

Noble, C., Withers, G. W., Ee, L. C. and Lewindon, P. J. (2009) Audit of eosinophilic oesophagitis in children post-liver transplantation. Pediatric Transplantation, 13 7: 827-830. doi:10.1111/j.1399-3046.2008.01063.x


Author Noble, C.
Withers, G. W.
Ee, L. C.
Lewindon, P. J.
Title Audit of eosinophilic oesophagitis in children post-liver transplantation
Journal name Pediatric Transplantation   Check publisher's open access policy
ISSN 1397-3142
Publication date 2009-11-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1399-3046.2008.01063.x
Volume 13
Issue 7
Start page 827
End page 830
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject C1
920501 Child Health
111403 Paediatrics
Abstract Pediatric liver transplantation has proven so successful that 10-yr survival post-transplantation is in excess of 70% and following transplantation, emphasis of medical care switches from life saving to promotion of good quality of life. EE is an increasingly recognised phenomenon in the general population. Eosinophilic disorders of the GI tract are increasingly recognised in patient's post-solid organ transplantation but the contribution of EE to morbidity in this population has not been addressed to date. The objective of this study was to identify the incidence of EE in children receiving liver transplantation by the QLTS over the last 15.5 yr. Comprehensive review of medical records of all liver transplant recipients during study period via cross-checking procedural and electronic laboratory results was performed. All oesophageal biopsies reporting mucosal inflammation were reviewed. EE can be diagnosed when oesophageal biopsy reveals ≥5 eosinophils per HPF; however, we used a cut-off of 20 eosinophils per HPF, which is in accordance with current opinion. In the 159 children who received DD OLT, 130 survived and four have been diagnosed with EE (3%). Only 34 are currently followed in Queensland and all four patients diagnosed are in this cohort representing 12% of our follow-up clinic. Many patients are followed elsewhere so occurrence of EE in our total surviving population is an underestimate. EE is clinically important in the post-liver transplant community. Children post-OLT who have upper GI symptoms should be considered for endoscopic evaluation and biopsy to exclude EE.
Keyword Eosinophilic oesophagitis
Liver transplantation
Morbidity
Gastro-oesophageal reflux
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 26 November 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Thu, 16 Apr 2009, 22:35:23 EST by Amanda Jones on behalf of Paediatrics & Child Health - RBWH