Fabrication and size-selective bioseparation of magnetic silica nanospheres with highly ordered periodic mesostructure

Zhang, Lei, Qiao, Shizhang, Jin, Yonggang, Yang, Huagui, Budihartono, Sandy, Stahr, Frances, Yan, Zifeng, Wang, Xiaolin, Hao, Zhengping and Lu, Gao Qing (2008) Fabrication and size-selective bioseparation of magnetic silica nanospheres with highly ordered periodic mesostructure. Advanced Functional Materials, 18 20: 3203-3212. doi:10.1002/adfm.200800363


Author Zhang, Lei
Qiao, Shizhang
Jin, Yonggang
Yang, Huagui
Budihartono, Sandy
Stahr, Frances
Yan, Zifeng
Wang, Xiaolin
Hao, Zhengping
Lu, Gao Qing
Title Fabrication and size-selective bioseparation of magnetic silica nanospheres with highly ordered periodic mesostructure
Journal name Advanced Functional Materials   Check publisher's open access policy
ISSN 1616-301X
1616-3028
Publication date 2008-10-23
Year available 2008
Sub-type Article (original research)
DOI 10.1002/adfm.200800363
Open Access Status Not yet assessed
Volume 18
Issue 20
Start page 3203
End page 3212
Total pages 10
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Language eng
Subject C1
100708 Nanomaterials
970103 Expanding Knowledge in the Chemical Sciences
1007 Nanotechnology
0303 Macromolecular and Materials Chemistry
0904 Chemical Engineering
0912 Materials Engineering
Abstract In this paper, we report a novel synthesis and selective bioseparation of the composite of Fe3O4 magnetic nanocrystals and highly ordered MCM-41 type periodic mesoporous silica nanospheres. Monodisperse superparamagnetic Fe3O4 nanocrystals were synthesized by thermal decomposition of iron stearate in diol in an autoclave at low temperature. The synthesized nanocrystals were encapsulated in mesoporous silica nanospheres through the packing and self-assembly of composite nanocrystal-surfactant micelles and surfactant/silica complex. Different from previous studies, the produced magnetic silica nanospheres (MSNs) possess not only uniform nanosize (90 similar to 140 nm) but also a highly ordered mesostructure. More importantly, the pore size and the saturation magnetization values can be controlled by using different alkyltrimethylammonium bromide surfactants and changing the amount of Fe3O4 magnetic nanocrystals encapsulated, respectively. Binary adsorption and desorption of proteins cytochrome c (cyt c) and bovine serum albumin (BSA) demonstrate that MSNs are an effective and highly selective adsorbent for proteins with different molecular sizes. Small particle size, high surface area, narrow pore size distribution, and straight pores of MSNs are responsible for the high selective adsorption capacity and fast adsorption rates. High magnetization values and superparamagnetic property of MSNs provide a convenient means to remove nanoparticles from solution and make the re-dispersion in solution quick following the withdrawal of an external magnetic field.
Formatted abstract
In this paper, we report a novel synthesis and selective bioseparation of the composite of Fe3O4 magnetic nanocrystals and highly ordered MCM-41 type periodic mesoporous silica nanospheres. Monodisperse superparamagnetic Fe3O4 nanocrystals were synthesized by thermal decomposition of iron stearate in diol in an autoclave at low temperature. The synthesized nanocrystals were encapsulated in mesoporous silica nanospheres through the packing and self-assembly of composite nanocrystal–surfactant micelles and surfactant/silica complex. Different from previous studies, the produced magnetic silica nanospheres (MSNs) possess not only uniform nanosize (90 ~140 nm) but also a highly ordered mesostructure. More importantly, the pore size and the saturation magnetization values can be controlled by using different alkyltrimethylammonium bromide surfactants and changing the amount of Fe3O4 magnetic nanocrystals encapsulated, respectively. Binary adsorption and desorption of proteins cytochrome c (cyt c) and bovine serum albumin (BSA) demonstrate that MSNs are an effective and highly selective adsorbent for proteins with different molecular sizes. Small particle size, high surface area, narrow pore size distribution, and straight pores of MSNs are responsible for the high selective adsorption capacity and fast adsorption rates. High magnetization values and superparamagnetic property of MSNs provide a convenient means to remove nanoparticles from solution and make the re-dispersion in solution quick following the withdrawal of an external magnetic field.
© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keyword Responsive controlled release
Mesoporous molecular sieves
Bovine serum albumin
Assisted synthesis
Mediated synthesis
Surfactant system
Cytochrome C
Nanoparticles
Adsorption
Nanocrystals
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP0452461
Institutional Status UQ

 
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Created: Thu, 16 Apr 2009, 22:13:12 EST by Amanda Lee on behalf of School of Chemical Engineering