Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres

Kirby, D. J., Rosenkrands, I., Agger, E. M., Andersen, P., Coombes, A. G. A. and Perrie, Y. (2008) Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres. Journal of Drug Targeting, 16 7-8: 543-554. doi:10.1080/10611860802228558

Author Kirby, D. J.
Rosenkrands, I.
Agger, E. M.
Andersen, P.
Coombes, A. G. A.
Perrie, Y.
Title Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres
Journal name Journal of Drug Targeting   Check publisher's open access policy
ISSN 1061-186X
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1080/10611860802228558
Open Access Status Not yet assessed
Volume 16
Issue 7-8
Start page 543
End page 554
Total pages 12
Editor Akhtar, S.
Place of publication United Kingdom
Publisher Informa Healthcare
Language eng
Subject C1
111504 Pharmaceutical Sciences
860801 Human Biological Preventatives (e.g. Vaccines)
Abstract The ability of liposomes and microspheres to enhance the efficacy of a sub-unit antigen was investigated. Microspheres were optimised by testing a range of surfactants employed in the external aqueous phase of a water-in-oil-in-water (w/o/w) double emulsion solvent evaporation process for the preparation of microspheres—composed of poly(d,l-lactide-co-glycolide) and the immunological adjuvant dimethyl dioctadecyl ammonium bromide (DDA)—and then investigated with regard to the physico-chemical and immunological characteristics of the particles produced. The results demonstrate that this parameter can affect the physico-chemical characteristics of these systems and subsequently, has a substantial bearing on the level of immune response achieved, both humoural and cell mediated, when employed for the delivery of the sub-unit tuberculosis vaccine antigen Ag85B-ESAT-6. Moreover, the microsphere preparations investigated failed to initiate immune responses at the levels achieved with an adjuvant DDA-based liposome formulation (DDA-TDB), further substantiating the superior ability of liposomes as vaccine delivery systems.
Keyword Microspheres
sub-unit vaccines
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 16 Apr 2009, 20:13:54 EST by Elizabeth Pyke on behalf of School of Pharmacy