Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine

Nayak, Usha Yogendra, Gopal, Shavi, Mutalik, Srinivas, Ranjith, Averinen Kumar, Reddy, Meka Sreenivasa, Gupta, Purushotham and Udupa, Nayanabhirama (2009) Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine. Journal of Microencapsulation, 26 3: 214-222. doi:10.1080/02652040802246325


Author Nayak, Usha Yogendra
Gopal, Shavi
Mutalik, Srinivas
Ranjith, Averinen Kumar
Reddy, Meka Sreenivasa
Gupta, Purushotham
Udupa, Nayanabhirama
Title Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine
Journal name Journal of Microencapsulation   Check publisher's open access policy
ISSN 0265-2048
1464-5246
Publication date 2009-05-01
Year available 2008
Sub-type Article (original research)
DOI 10.1080/02652040802246325
Open Access Status
Volume 26
Issue 3
Start page 214
End page 222
Total pages 9
Editor A. L. Whateley
O. Alpar
Place of publication London, England
Publisher Taylor & Francis
Language eng
Subject C1
111504 Pharmaceutical Sciences
860899 Human Pharmaceutical Products not elsewhere classified
Abstract Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2% acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60-210 µm, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60% of entrapment and release was extended up to 18-24 h. Among all the systems studied, the 35% Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75% release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drug-polymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.
Keyword Zidovudine
microspheres
chitosan
glutaraldehyde
kinetic models
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Thu, 16 Apr 2009, 02:37:28 EST by Elizabeth Pyke on behalf of School of Pharmacy