Structure-based Drug Design and NMR-based screening

Craik, D. J. and Clark, R. J. (2008). Structure-based Drug Design and NMR-based screening. In R. A. Meyers (Ed.), Pharmacology from drug development to gene therapy (pp. 225-313) Weinheim: Wiley-VCH Verlag GMBH & Co.

Author Craik, D. J.
Clark, R. J.
Title of chapter Structure-based Drug Design and NMR-based screening
Title of book Pharmacology from drug development to gene therapy
Place of Publication Weinheim
Publisher Wiley-VCH Verlag GMBH & Co
Publication Year 2008
Sub-type Research book chapter (original research)
Year available 2008
ISBN 978-3-527-32343-2
Editor R. A. Meyers
Volume number 1
Chapter number 8
Start page 225
End page 313
Total pages 88
Total chapters 33
Collection year 2009
Language eng
Subjects B1
030401 Biologically Active Molecules
970103 Expanding Knowledge in the Chemical Sciences
Abstract/Summary NMR spectroscopy is a powerful technique for determining the structures of molecules in solution. It involves placing a sample in a powerful magnetic field and irradiating it with radio waves of defined frequency. The emitted signals provide information about the local molecular environments of nuclei in the sample, from which structures can be derived.
Keyword Chemical shift
chemical shift mapping
HSQC spectroscopy
Isotope labeling
NMR screening
NOE
Pulse Sequencce
Q-Index Code B1
Q-Index Status Confirmed Code

 
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Created: Wed, 15 Apr 2009, 15:59:03 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience